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Application of cyclic aspiration using an aspiration catheter is a current therapy for the removal of lodged clots. In this study, we perform finite element simulations to analyze deformation of long clots, having length to radius ratio of 2\u201310, which corresponds to clot\u2010length of 2.85\u201314.25\u2009mm, under peak\u2010to\u2010peak cyclic aspiration pressures of 10\u201350\u2009mmHg, and frequencies of 0.5, 1, and 2\u2009Hz. Our computational system comprises of a nonlinear viscoelastic solid clot, a hyperelastic artery, and a nonlinear viscoelastic cohesive zone, the latter modeling the clot\u2013artery interface. We observe that clots having length\u2010to\u2010radius ratio approximately greater than two separate from the inner arterial surface somewhere between the axial and distal ends, irrespective of the cyclic aspiration loading conditions. The stress distribution within the clot shows large tensile stresses in the clot interior, indicating the possibility of simultaneous fragmentation of the clot. Thus, this study shows us the various failure mechanisms simultaneously present in the clot during cyclic aspiration. Similarly, the stress distribution within the artery implies a possibility of endothelial damage to the arterial wall near the end where the aspiration pressure is applied. This framework provides a foundation for further investigation to clot fracture and adhesion characterization.<\/jats:p>","DOI":"10.1002\/cnm.3667","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T10:05:32Z","timestamp":1670925932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Computational analysis of effects of clot length on Acute ischemic stroke recanalization under different cyclic aspiration loading conditions"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-2131","authenticated-orcid":false,"given":"Priyanka","family":"Patki","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of 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