{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:32:44Z","timestamp":1791261164435,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["740132"],"award-info":[{"award-number":["740132"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcatheter aortic valve implantation (TAVI) is a minimally invasive intervention for the treatment of severe aortic valve stenosis. The main cause of failure is the structural deterioration of the implanted prosthetic leaflets, possibly inducing a valvular re\u2010stenosis 5\u201310\u2009years after the implantation. Based solely on pre\u2010implantation data, the aim of this work is to identify fluid\u2010dynamics and structural indices that may predict the possible valvular deterioration, in order to assist the clinicians in the decision\u2010making phase and in the intervention design. Patient\u2010specific, pre\u2010implantation geometries of the aortic root, the ascending aorta, and the native valvular calcifications were reconstructed from computed tomography images. The stent of the prosthesis was modeled as a hollow cylinder and virtually implanted in the reconstructed domain. The fluid\u2010structure interaction between the blood flow, the stent, and the residual native tissue surrounding the prosthesis was simulated by a computational solver with suitable boundary conditions. Hemodynamical and structural indicators were analyzed for five different patients that underwent TAVI \u2013 three with prosthetic valve degeneration and two without degeneration \u2013 and the comparison of the results showed a correlation between the leaflets' structural degeneration and the wall shear stress distribution on the proximal aortic wall. This investigation represents a first step towards computational predictive analysis of TAVI degeneration, based on pre\u2010implantation data and without requiring additional peri\u2010operative or follow\u2010up information. Indeed, being able to identify patients more likely to experience degeneration after TAVI may help to schedule a patient\u2010specific timing of follow\u2010up.<\/jats:p>","DOI":"10.1002\/cnm.3704","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T09:14:10Z","timestamp":1679908450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Fluid\u2010structure interaction analysis of transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-1398","authenticated-orcid":false,"given":"Ivan","family":"Fumagalli","sequence":"first","affiliation":[{"name":"MOX, Dipartimento di Matematica Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Polidori","sequence":"additional","affiliation":[{"name":"LaBS, Dipartimento di Chimica, Materiali e Ingegneria Chimica Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Renzi","sequence":"additional","affiliation":[{"name":"LaBS, Dipartimento di Chimica, Materiali e Ingegneria Chimica Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fusini","sequence":"additional","affiliation":[{"name":"Department of Perioperative Cardiology and Cardiovascular Imaging Centro Cardiologico Monzino IRCSS  Milan Italy"},{"name":"Department of Electronics, Information and Biomedical Engineering Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfio","family":"Quarteroni","sequence":"additional","affiliation":[{"name":"MOX, Dipartimento di Matematica Politecnico di Milano  Milan Italy"},{"name":"Institute of Mathematics \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pontone","sequence":"additional","affiliation":[{"name":"Department of Perioperative Cardiology and Cardiovascular Imaging Centro Cardiologico Monzino IRCSS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-5410","authenticated-orcid":false,"given":"Christian","family":"Vergara","sequence":"additional","affiliation":[{"name":"LaBS, Dipartimento di Chimica, Materiali e Ingegneria Chimica Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2005.03.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.5.1105"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12572-015-0139-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.595"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-020-01304-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-019-00427-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-013-0996-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex046"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.07.38"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018506"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08747-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.15420\/icr.2019.4.2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2021.1906233"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2017.06.045"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-020-02138-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66899-6"},{"issue":"418","key":"e_1_2_7_20_1","first-page":"428","article-title":"Aortic flow patterns after simulated implantation of transcatheter aortic valves","volume":"56","author":"Kopanidis A","year":"2015","journal-title":"Hell J Cardiol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4040457"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-018-1094-8"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.577188"},{"key":"e_1_2_7_24_1","first-page":"1","article-title":"The impact of calcification patterns in transcatheter aortic valve performance: a fluid\u2010structure interaction analysis","volume":"24","author":"Luraghi G","year":"2020","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2020.08.037"},{"key":"e_1_2_7_26_1","first-page":"53","article-title":"Current TAVR devices","volume":"11","author":"Todaro D","year":"2017","journal-title":"Card Intervent Today"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.15420\/icr.2011.9.2.121"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-008-0420-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1145\/37402.37422"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.812261"},{"key":"e_1_2_7_31_1","first-page":"35","volume-title":"Discrete Differential\u2010Geometry Operators for Triangulated 2\u2010Manifolds","author":"Meyer M","year":"2003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.06.020"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4040940"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0962492917000046"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-7825(82)90128-1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2016.10.005"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/fld.843"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2156(08)70153-4"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amc.2017.01.032"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2014.05.020"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1137\/090772836"},{"key":"e_1_2_7_42_1","article-title":"The LifeV library: engineering mathematics beyond the proof of concept","author":"Bertagna L","year":"2017","journal-title":"arXiv:1710.06596"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2013.03.022"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2017.05.008"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2017.06.030"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.103922"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3447"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4050910"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.09.027"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2006.11.001"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2008.01.004"},{"key":"e_1_2_7_52_1","first-page":"29","article-title":"TAVI 2018: from guidelines to practice","volume":"15","author":"Khosravi A","year":"2018","journal-title":"Eur J Cardiol Pract"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.2.377"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy126"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2016.01.007"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.3704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T15:56:52Z","timestamp":1692460612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.3704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,5]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/cnm.3704"],"URL":"https:\/\/doi.org\/10.1002\/cnm.3704","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,5]]},"assertion":[{"value":"2022-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3704"}}