{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:46:47Z","timestamp":1789753607238,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009374","name":"Pakistan Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extra corporeal membrane oxygenation (ECMO) is an artificial oxygenation facility, employed in situations of cardio\u2010pulmonary failure. Some diseases i.e., acute respiratory distress syndrome, pulmonary hypertension, corona virus disease (COVID\u201019) etc. affect oxygenation performance of the lungs thus requiring the need of artificial oxygenation. Critical care teams used ECMO technique during the COVID\u201019 pandemic to support the heart and lungs of COVID\u201019 patients who had an acute respiratory or cardiac failure. Double Lumen Cannula (DLC) is one of the most critical components of ECMO as it resides inside the patient and, connects patient with external oxygenation circuit. DLC facilitates delivery and drainage of blood from the patient's body. DLC is characterized by delicate balance of internal and external flows inside a limited space of the right atrium (RA). An optimal performance of the DLC necessitates structural stability under biological and hemodynamic loads, a fact that has been overlooked by previously published studies. In the past, many researchers experimentally and computationally investigated the hemodynamic performance of DLC by employing Eulerian approach, which evaluate instantaneous blood damage without considering blood shear exposure history (qualitative assessment only). The present study is an attempt to address the aforementioned limitations of the previous studies by employing Lagrangian (quantitative assessment) and incorporating the effect of fluid\u2013structure interaction (FSI) to study the hemodynamic performance of neonatal DLC. The study was performed by solving three\u2010dimensional continuity, momentum, and structural mechanics equation(s) by numerical methods for the blood flow through neonatal DLC. A two\u2010way coupled FSI analysis was performed to analyze the effect of DLC structural deformation on its hemodynamic performance. Results show that the return lumen was the most critical section with maximum pressure drop, velocity, shear stresses, and blood damage. Recirculation and residence time of blood in the right atrium (RA) increases with increasing blood flow rates. Considering the structural deformation has\u00a0led to higher blood damage inside the DLC\u2010atrium system. Maximum Von\u2010Mises stress was present on the side edges of the return lumen that showed direct proportionality with the blood flow rate.<\/jats:p>","DOI":"10.1002\/cnm.3706","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T12:11:39Z","timestamp":1681215099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemodynamic performance evaluation of neonatal <scp>ECMO<\/scp> double lumen cannula using <scp>fluid\u2013structure<\/scp> interaction"],"prefix":"10.1002","volume":"39","author":[{"given":"Faiq","family":"Ahmad","sequence":"first","affiliation":[{"name":"Faculty of Mechanical Engineering GIK Institute of Engineering Sciences and Technology  Topi, 23460, KPK Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taqi Ahmad","family":"Cheema","sequence":"additional","affiliation":[{"name":"Faculty of Mechanical Engineering GIK Institute of Engineering Sciences and Technology  Topi, 23460, KPK Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khawar","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Hanyang University  Seoul 04763 South Korea"},{"name":"Department of Civil Engineering GIK Institute of Engineering Sciences and Technology  Topi, 23460, KPK Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhaj","family":"Ullah","sequence":"additional","affiliation":[{"name":"Faculty of Mechanical Engineering GIK Institute of Engineering Sciences and Technology  Topi, 23460, KPK Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Jamil","sequence":"additional","affiliation":[{"name":"Analysis Group Starfish Medical  455 Boleskine Rd Victoria British Columbia Canada"},{"name":"Department of Mechanical Engineering Ko\u00c7 University  Sariyar Istanbul 34450 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-1558","authenticated-orcid":false,"given":"Cheol Woo","family":"Park","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Kyungpook National University  80 Daehak\u2010Ro, Buk\u2010Gu Daegu 41566 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"4","article-title":"Cannulation techniques for extracorporeal life support","volume":"5","author":"Pavlushko E","year":"2017","journal-title":"Ann Transl 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