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Untreated aortic dissection can lead to myocardial infarction, aortic branch malperfusion or occlusion, rupture, aneurysm formation and death. This study aims to assess the potential of a biomechanical model in predicting the risks of a non\u2010dilated thoracic aorta with Stanford type A dissection. To achieve this, a fully coupled fluid\u2013structure interaction model was developed under realistic blood flow conditions. This model of the aorta was developed by considering three\u2010dimensional artery geometry, multiple artery layers, hyperelastic artery wall, in vivo\u2010based physiological time\u2010varying blood velocity profiles, and non\u2010Newtonian blood behaviours. The results demonstrate that in a thoracic aorta with Stanford type A dissection, the wall shear stress (WSS) is significantly low in the ascending aorta and false lumen, leading to potential aortic dilation and thrombus formation. The results also reveal that the WSS is highly related to blood flow patterns. The aortic arch region near the brachiocephalic and left common carotid artery is prone to rupture, showing a good agreement with the clinical reports. The results have been translated into their potential clinical relevance by revealing the role of the stress state, WSS and flow characteristics as the main parameters affecting lesion progression, including rupture and aneurysm. The developed model can be tailored for patient\u2010specific studies and utilised as a predictive tool to estimate aneurysm growth and initiation of wall rupture inside the human thoracic aorta.<\/jats:p>","DOI":"10.1002\/cnm.3736","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T01:55:12Z","timestamp":1685584512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fluid\u2013structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-1609","authenticated-orcid":false,"given":"Xiaochen","family":"Wang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering University of Adelaide  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mergen 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