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We adapted a continuum\u2010based numerical modeling approach for the lung, integrating the fluid mechanics of the airflow within individual generations of the bronchi and alveoli. The model accounts for elasticity of the deformable bronchioles, resistance to airflow due to the presence of mucus within the bronchioles, and subsequent mucus flow. Simulated quasi\u2010dynamic inhalation and expiration cycles were used to characterize the net compliance and resistance of the lung, considering the rheology of the mucus and viscoelastic properties of the parenchyma tissue. The structure and material properties of the lung were identified to have an important contribution to the lung compliance and airflow resistance. The secondary objective of this work was to assess whether a higher frequency and smaller volume of harmonic air flow rate compared to a normal ventilator breathing cycle enhanced mucus outflow. Results predict, lower mucus viscosity and higher excitation frequency of breathing are favorable for the flow of mucus up the bronchi tree, towards the trachea.<\/jats:p>","DOI":"10.1002\/cnm.3744","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T06:48:21Z","timestamp":1687157301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>Quasi\u2010dynamic<\/scp> breathing model of the lung incorporating viscoelasticity of the lung tissue"],"prefix":"10.1002","volume":"39","author":[{"given":"Nitin","family":"Daphalapurkar","sequence":"first","affiliation":[{"name":"Fluid Dynamics and Solid Mechanics T\u20103, Los Alamos National Laboratory  Los Alamos New Mexico 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