{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:02Z","timestamp":1786977602130,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bone scaffolding is a promising approach for the treatment of critical\u2010size bone defects. Hydroxyapatite can be used to produce highly porous scaffolds as it mimics the mineralized part of bone tissue, but its intrinsic brittleness limits its usage. Among 3D printing techniques, vat photopolymerization allows for the best printing resolution for ceramic materials. In this study, we implemented a Computed micro\u2010Tomography based Finite Element Model of a hydroxyapatite porous scaffold fabricated by vat photopolymerization. We used the model in order to predict the elastic and fracture properties of the scaffold. From the stress\u2013strain diagram of a simulated compression test, we computed the stiffness and the strength of the scaffolds. We found that three morphometric features substantially affect the crack pattern. In particular, the crack propagation is not only dependent on the trabecular thickness but also depends on the slenderness and orientation of the trabeculae with respect to the load. The results found in this study can be used for the design of ceramic scaffolds with heterogeneous pore distribution in order to tailor and predict the compressive strength.<\/jats:p>","DOI":"10.1002\/cnm.3795","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:48:59Z","timestamp":1700786939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Computational models for the simulation of the elastic and fracture properties of highly porous\n                    <scp>3D<\/scp>\n                    \u2010printed hydroxyapatite scaffolds"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-8338","authenticated-orcid":false,"given":"Luca","family":"D'Andrea","sequence":"first","affiliation":[{"name":"Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gastaldi","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Baino","sequence":"additional","affiliation":[{"name":"Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino Institute of Materials Physics and Engineering  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Vern\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino Institute of Materials Physics and Engineering  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schwentenwein","sequence":"additional","affiliation":[{"name":"Lithoz GmbH  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gissur","family":"\u00d6rlygsson","sequence":"additional","affiliation":[{"name":"IceTec  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Vena","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Biology of Bone Tissue: Structure, Function, and Factors that Influence Bone Cells","author":"Florencio\u2010Silva 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