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Recently, additive manufacturing has become a promising technique for the fabrication of medical devices, because it allows to produce complex samples with various structures of pores. Moreover, the limitations of traditional fabrication methods can be avoided. It is known that a well\u2010designed porous structure provides a better proliferation of cells, leading to improved bone remodeling. Additionally, porosity can be used to adjust the mechanical properties of designed structures. This makes the design and choice of the structure's basic cell a crucial task. This study focuses on a novel computational method, based on the basic\u2010cell concept to design a hip endoprosthesis with an unregularly complex structure. A cube with spheroid pores was utilized as a basic cell, with each cell having its own porosity and mechanical properties. A novelty of the suggested method is in its combination of the topology optimization method and the structural design algorithm. Bending and compression cases were analyzed for a cylinder structure and two hip implants. The ability of basic\u2010cell geometry to influence the structure's stress\u2013strain state was shown. The relative change in the volume of the original structure and the designed cylinder structure was 6.8%. Computational assessments of a stress\u2013strain state using the proposed method and direct modeling were carried out. The volumes of the two types of implants decreased by 9% and 11%, respectively. The maximum von Mises stress was 600\u2009MPa in the initial design. After the algorithm application, it increased to 630\u2009MPa for the first type of implant, while it is not changing in the second type of implant. At the same time, the load\u2010bearing capacity of the hip endoprostheses was retained. The internal structure of the optimized implants was significantly different from the traditional designs, but better structural integrity is likely to be achieved with less material. Additionally, this method leads to time reduction both for the initial design and its variations. Moreover, it enables to produce medical implants with specific functional structures with an additive manufacturing method avoiding the constraints of traditional technologies.<\/jats:p>","DOI":"10.1002\/cnm.3802","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T01:05:55Z","timestamp":1705885555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Method of computational design for additive manufacturing of hip endoprosthesis based on basic\u2010cell concept"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-9485","authenticated-orcid":false,"given":"Pavel","family":"Bolshakov","sequence":"first","affiliation":[{"name":"Department of Machine Science and Engineering Graphics Tupolev Kazan National Research Technical University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-175X","authenticated-orcid":false,"given":"Alex G.","family":"Kuchumov","sequence":"additional","affiliation":[{"name":"Department of Computational Mathematics, Mechanics and Biomechanics Perm National Research Polytechnic University  Perm Russia"},{"name":"Laboratory of Mechanics of Biocompatible Materials and Devices Perm National Research Polytechnic University  Perm Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-143X","authenticated-orcid":false,"given":"Nikita","family":"Kharin","sequence":"additional","affiliation":[{"name":"Department of Theoretical Mechanics, N.I. Lobachevsky Institute of Mathematics and Mechanics Kazan Federal University  Kazan Russia"},{"name":"Institute of Engineering Kazan Federal University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Akifyev","sequence":"additional","affiliation":[{"name":"Department of Theoretical Mechanics, N.I. 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