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Despite its demonstrated efficacy, the LAA morphological complexity hinders the procedure, resulting in postprocedural drawbacks (device\u2010related thrombus and peri\u2010device leakage). Local anatomical features may cause difficulties in the device's positioning and affect the effectiveness of the device's implant. The current work proposes a detailed FE model of the LAAO useful to investigate implant scenarios and derive clinical indications. A high\u2010fidelity model of the Watchman FLX device and simplified parametric conduits mimicking the zone of the LAA where the device is deployed were developed. Device\u2010conduit interactions were evaluated by looking at clinical indicators such as device\u2010wall gap, possible cause of leakage, and device protrusion. As expected, the positioning of the crimped device before the deployment was found to significantly affect the implant outcomes: clinician's choices can be improved if FE models are used to optimize the pre\u2010operative planning. Remarkably, also the wall mechanical stiffness plays an important role. However, this parameter value is unknown for a specific LAA, a crucial point that must be correctly defined for developing an accurate FE model. Finally, numerical simulations outlined how the device's configuration on which the clinician relies to assess the implant success (i.e., the deployed configuration with the device still attached to the catheter) may differ from the actual final device's configuration, relevant for achieving a safe intervention.<\/jats:p>","DOI":"10.1002\/cnm.3814","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T01:49:30Z","timestamp":1710899370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Left atrial appendage occlusion: On the need of a numerical model to simulate the implant procedure"],"prefix":"10.1002","volume":"40","author":[{"given":"Francesca","family":"Danielli","sequence":"first","affiliation":[{"name":"LaBS \u2010 Laboratory of Biological Structure Mechanics, Department of Chemistry Materials and Chemical Engineering \u201cGiulio Natta\u201d, Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-2503","authenticated-orcid":false,"given":"Francesca","family":"Berti","sequence":"additional","affiliation":[{"name":"LaBS \u2010 Laboratory of Biological Structure Mechanics, Department of Chemistry Materials and Chemical Engineering \u201cGiulio Natta\u201d, Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benigno Marco","family":"Fanni","sequence":"additional","affiliation":[{"name":"BioCardioLab Fondazione Toscana G. 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