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Patient\u2010specific and well\u2010tuned boundary conditions are key to obtaining accurate and reliable hemodynamic results. However, CFD simulations are usually performed under non\u2010patient\u2010specific flow conditions due to the absence of in vivo flow and pressure measurements. This study proposes a new method to overcome this challenge by tuning inlet boundary conditions using data extracted from electrocardiogram (ECG). Five patient\u2010specific geometric models of type B aortic dissection were reconstructed from computed tomography (CT) images. Other available data included stoke volume (SV), ECG, and 4D\u2010flow magnetic resonance imaging (MRI). ECG waveforms were processed to extract patient\u2010specific systole to diastole ratio (SDR). Inlet boundary conditions were defined based on a generic aortic flow waveform tuned using (1) SV only, and (2) with ECG and SV (ECG\u2009+\u2009SV). 4D\u2010flow MRI derived inlet boundary conditions were also used in patient\u2010specific simulations to provide the gold standard for comparison and validation. Simulations using inlet flow waveform tuned with ECG\u2009+\u2009SV not only successfully reproduced flow distributions in the descending aorta but also provided accurate prediction of time\u2010averaged wall shear stress (TAWSS) in the primary entry tear (PET) and abdominal regions, as well as maximum pressure difference, <jats:italic>\u2206P<\/jats:italic><jats:sub>max<\/jats:sub>, from the aortic root to the distal false lumen. Compared with simulations with inlet waveform tuned with SV alone, using ECG\u2009+\u2009SV in the tuning method significantly reduced the error in false lumen ejection fraction at the PET (from 149.1% to 6.2%), reduced errors in TAWSS at the PET (from 54.1% to 5.7%) and in the abdominal region (from 61.3% to 11.1%), and improved <jats:italic>\u2206P<\/jats:italic><jats:sub>max<\/jats:sub> prediction (from 283.1% to 18.8%) However, neither of these inlet waveforms could be used for accurate prediction of TAWSS in the ascending aorta. This study demonstrates the importance of SDR in tailoring inlet flow waveforms for patient\u2010specific hemodynamic simulations. A well\u2010tuned flow waveform is essential for ensuring that the simulation results are patient\u2010specific, thereby enhancing the confidence and fidelity of computational tools in future clinical applications.<\/jats:p>","DOI":"10.1002\/cnm.3855","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T09:21:23Z","timestamp":1721899283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A new method for scaling inlet flow waveform in hemodynamic analysis of aortic dissection"],"prefix":"10.1002","volume":"40","author":[{"given":"Kaihong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chl\u00f6e H.","family":"Armour","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Imperial College London  London 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