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This \u201cproof of principle\u201d investigation is the initial step towards the design of a new plate using alternative materials to address some of these problems. Finite element modeling was used to create design graphs for bone stress, plate stress, screw stress, and interfragmentary motion via three different fixations (no, 1, or 2 \u201ckickstand\u201d [KS] screws across the fracture) using a wide range of plate elastic moduli (<jats:italic>E<\/jats:italic><jats:sub>P<\/jats:sub>\u2009=\u20095\u2013200\u2009GPa). Well\u2010known design optimization criteria were used that could minimize bone, plate, and screw failure (i.e., peak stress\u2009&lt;\u2009ultimate tensile strength), reduce bone \u201cstress shielding\u201d (i.e., bone stress under the new plate\u2009\u2265\u2009bone stress for an intact humerus, titanium plate, and\/or steel plate \u201ccontrol\u201d), and encourage callus growth leading to early healing (i.e., 0.2\u2009mm\u2009\u2264\u2009axial interfragmentary motion\u2009\u2264\u20091\u2009mm; shear\/axial interfragmentary motion ratio &lt;1.6). The findings suggest that a potentially optimal configuration involves the new plate being manufactured from a material with an <jats:italic>E<\/jats:italic><jats:sub>P<\/jats:sub> of 5\u201341.5\u2009GPa with 1 KS screw; but, using no KS screws would cause immediate bone fracture and 2 KS screws would almost certainly lead to delayed healing. A prototype plate might be fabricated using alternative materials suggested for orthopedics and other industries, like fiber\u2010metal laminates, fiber\u2010reinforced polymers, metal foams, pure polymers, shape memory alloys, or 3D\u2010printed porous metals.<\/jats:p>","DOI":"10.1002\/cnm.3868","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T09:59:57Z","timestamp":1725703197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biomechanical design of a new proximal humerus fracture plate using alternative materials"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5920-9800","authenticated-orcid":false,"given":"Sabrina","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering George Mason University  Fairfax Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6993-0942","authenticated-orcid":false,"given":"Mitchell","family":"Dembowski","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Toronto Metropolitan University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-9069","authenticated-orcid":false,"given":"Emil H.","family":"Schemitsch","sequence":"additional","affiliation":[{"name":"Orthopaedic Biomechanics Lab Victoria Hospital  London Ontario Canada"},{"name":"Division of Orthopaedic Surgery Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6678-570X","authenticated-orcid":false,"given":"Habiba","family":"Bougherara","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Toronto Metropolitan University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-9202","authenticated-orcid":false,"given":"Z. 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