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Hence, effective mechanical conditions of the healing process of tibia can be categorized into the material of the plate and screws, post\u2010operation loadings, and screw type and pressure. In this paper, a mathematical biodegradation model was used to simulate the PGF\/PLA plate\u2010screw device over 8\u2009weeks. The effect of different post\u2010operation loading patterns was studied for both locking and non\u2010locking screws. The aim was to reach the best configuration for the most achievable healing using FEA by computing the healing pattern, trend, and efficiency with the mechano\u2010regulation theory based on deviatoric strain. The biodegradation process of the plate and screws resulted in 82% molecular weight loss and 1.05\u2009GPa decrease in Young's modulus during 8\u2009weeks. The healing efficiency of the cases ranged from 4.72% to 14.75% in the first week and 18.64% to 63.05% in the eighth week. Finally, an optimal case was achieved by considering the prevention of muscle erosion, bone density reduction, and nonunion, according to the obtained results.<\/jats:p>","DOI":"10.1002\/cnm.3870","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T06:50:40Z","timestamp":1727333440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impacts of post\u2010operation loading and fixation implant on the healing process of fractured tibia"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-1260","authenticated-orcid":false,"given":"Shima","family":"Doorandish Yazdi","sequence":"first","affiliation":[{"name":"Faculty of New Sciences and Technologies, Department of Life Science Engineering University of Tehran  Tehran 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