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In clinical practice, the diameter of the stent forming a shunt is usually selected empirically, which will influence the postoperative portal pressure. Clinical studies found that inappropriate portal pressure after TIPS is responsible for poor prognosis; however, there is no scheme to predict postoperative portal pressure. Therefore, this study aims to develop a computational model applied to predict the portal pressure after TIPS ahead of the surgery. For this purpose, a patient\u2010specific 0\u20103\u2010D multi\u2010scale computational model of the hepatic circulation was developed based on preoperative clinical data. The model was validated using the prospectively collected clinical data of 18 patients. Besides, the model of a representative patient was employed in the numerical experiment to further investigate the influences of multiple pathophysiological and surgical factors. Results showed that the difference between the simulated and in\u00a0vivo measured portal pressures after TIPS was \u22121.37\u2009\u00b1\u20093.51\u2009mmHg, and the simulated results were significantly correlated with the in\u00a0vivo measured results (<jats:italic>r<\/jats:italic>\u2009=\u20090.93, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Numerical experiment revealed that the estimated model parameters and the severity of possible inherent portosystemic collaterals slightly influenced the simulated results, while the shunt diameter considerably influenced the results. In particular, the existence of catheter for pressure measurement would markedly influence postoperative portal pressure. These findings demonstrated that this computational model is a promising tool for predicting postoperative portal pressure, which would guide the selection of stent diameter and promote individualization and precision of TIPS.<\/jats:p>","DOI":"10.1002\/cnm.3908","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T07:03:49Z","timestamp":1737702229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Multi\u2010Scale Computational Model of the Hepatic Circulation Applied to Predict the Portal Pressure After Transjugular Intrahepatic Portosystemic Shunt (<scp>TIPS<\/scp>)"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5289-4737","authenticated-orcid":false,"given":"Tianqi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Gongli Hospital Medical Technology University of Shanghai for Science and Technology  Shanghai China"},{"name":"School of Mechanical Engineering University of Shanghai for Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-7371","authenticated-orcid":false,"given":"Yi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Department of Radiology Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &amp; Interventional Radiology (Southeast University)  Nanjing China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University; State Key Laboratory of Digital Medical Engineering  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitao","family":"Wang","sequence":"additional","affiliation":[{"name":"Xingtai Key Laboratory of Precision Medicine for Liver Cirrhosis and Portal Hypertension Xingtai People's Hospital, Hebei Medical University  Xingtai China"},{"name":"School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Gu","sequence":"additional","affiliation":[{"name":"Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Department of Radiology Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &amp; Interventional Radiology (Southeast University)  Nanjing China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University; State Key Laboratory of Digital Medical Engineering  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Department of Radiology Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &amp; Interventional Radiology (Southeast University)  Nanjing China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University; State Key Laboratory of Digital Medical Engineering  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine  Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhu","sequence":"additional","affiliation":[{"name":"First Department of Intervention The Sixth People's Hospital of Shenyang  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Suining Central Hospital  Suining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The Six Affiliated Hospital of Nantong University (Yancheng Third People's Hospital)  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Interventional and Vascular Surgery Zhongda Hospital, Medical School, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Zhongda Hospital, Medical School, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deping","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine  Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"First Department of Intervention The Sixth People's Hospital of Shenyang  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Suining Central Hospital  Suining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoguang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The Six Affiliated Hospital of Nantong University (Yancheng Third People's Hospital)  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-5855","authenticated-orcid":false,"given":"Xiaolong","family":"Qi","sequence":"additional","affiliation":[{"name":"Hebei Provincial Key Laboratory of Portal Hypertension and Cirrhosis, Xingtai People\u2019s Hospital, Xingtai, China; 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