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Considering axisymmetric stenosis in straight arteries along with clinically observed dimensions of the arteries and enveloping tissue, the present numerical study considers blood as a Newtonian fluid and both artery and tissue as isotropic and geometrically nonlinear (materialistically linear) solid. For the physiological fluid flexible\u2010structure acoustic interaction (FfSAI) study, an in\u2010house multiphysics solver is used for a parametric study\u2014using various stenosis level  (60%, 70%, and 80%) and stenosis length  (2<jats:italic>D<\/jats:italic> and 4<jats:italic>D<\/jats:italic>); for each of the arteries. With increasing , an increase in acoustic acceleration's FFT spectrum\u2010based cut\u2010off frequency  is found\u2014indicating possibility of quantitative phonoangiographic diagnosis. The variation of this frequency  with  follows similar trend as that of frequency calculated by pressure fluctuation's FFT spectrum, thus correlating the hemodynamics as the cause for generation of the sound\/bruits. Also, a flow\u2010visualization\u2010based frequency, which is calculated using vortex length and velocity during vortex dissipation stage, matches reasonably (\u2264\u200915% difference) with the cut\u2010off frequency of pressure fluctuation. For the first time in the literature, our sound velocity level\u2010based study shows over\u2010prediction of stenosis by neglecting flow\u2010induced tissue deformations. This implies the importance of modeling structural flexibility, along with flow and acoustics while developing a computational Point\u2010of\u2010Care diagnostic tool. Finally, using analytical method for acoustics, a computationally efficient semi\u2010analytical FfSAI approach is proposed. The present work is significant since an accurate and computationally efficient framework and flow\u2010physics\u2010based analysis are presented for phonoangiographic diagnosis of stenosed arteries of three types.<\/jats:p>","DOI":"10.1002\/cnm.70021","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T02:49:52Z","timestamp":1740365392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phonoangiographic Diagnosis of Stenosed Arteries: A Computational Fluid Flexible\u2010Structure Acoustic Interaction Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5776-5184","authenticated-orcid":false,"given":"Sumant R.","family":"Morab","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering Indian Institute of Technology Bombay  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-8747","authenticated-orcid":false,"given":"Janani S.","family":"Murallidharan","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Indian Institute of Technology Bombay  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Indian Institute of Technology Bombay  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(87)90186-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2014.12.008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.04.027"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.2.935"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.12.6.798"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.3426239"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02510784"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197511272932205"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.121649"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(76)90105-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002211200300449X"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apm.2011.11.065"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-020-02119-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.5005622"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-012-0917-5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2017.02.018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsvi.2002.5001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4036262"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00311844"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112007005848"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2015.1113406"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4006681"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2598"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2732"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2514\/1.3001"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.718540"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0203193"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/jfm.2014.535"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/2\/2\/305"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2023.109054"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218396X01000541"},{"issue":"1","key":"e_1_2_11_34_1","first-page":"534","article-title":"Numerical Method for Fluid Structure Acoustic Interaction on a Unified 2d Cartesian and Axisymmetric Coordinates","volume":"2","author":"Morab S. 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