{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:02:20Z","timestamp":1779174140204,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1000200"],"award-info":[{"award-number":["2021YFA1000200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1000202"],"award-info":[{"award-number":["2021YFA1000202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024\u2009M763115"],"award-info":[{"award-number":["2024\u2009M763115"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12202022"],"award-info":[{"award-number":["12202022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271361"],"award-info":[{"award-number":["32271361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12102014"],"award-info":[{"award-number":["12102014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["4242032"],"award-info":[{"award-number":["4242032"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Superficial temporal artery and middle cerebral artery (STA\u2013MCA) bypass surgery is an effective method to enhance cerebral blood flow (CBF) in ischemic patients. However, the effectiveness of various bypass techniques varies with the diversity of Circle of Willis (CoW) structures. This study aims to develop a physiologically realistic hemodynamic model to optimize STA\u2013MCA bypass planning for cerebral ischemia patients with different CoW structures. This study developed a 0D\u20131D geometric multi\u2010scale haemodynamic model that coupled the stenosis model and the cerebral autoregulation model. Based on this model, nine CoW structural models before and after end\u2010to\u2010side (E\u2013S) and side\u2010to\u2010side (S\u2013S) bypass were constructed, and their haemodynamic properties were calculated to evaluate the efficacy of different bypass methods in different CoW structures. The validity of the model and results was verified by clinical data. For the mRACA1, mRACA1\u2013fRPCA1, and mACoA CoW structures, there was a risk of hyperperfusion (13.96%, 12.81%, and \u22122.64%) after E\u2013S bypass but not S\u2013S bypass. In the mACoA\u2013mLPCoA structure, both bypass techniques posed hyperperfusion risk (112.41% and 30.57%). Other CoW structures showed that E\u2013S bypass could restore CBF without the risk of hyperperfusion. The model's predictions were within 5% of clinical data. The mRACA1, mRACA1\u2013fRPCA1, and mACoA structures were suitable for S\u2010S bypass; the mACoA\u2013mLPCoA structure was not suitable for bypass, and other CoW structures favored E\u2013S bypass. The developed model can effectively simulate the cerebral hemodynamic environment and predict the risk of hyperperfusion, offering valuable insights for personalized bypass planning in cerebral ischemia patients.<\/jats:p>","DOI":"10.1002\/cnm.70026","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:44:55Z","timestamp":1741736695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Superficial Temporal Artery\u2013Middle Cerebral Artery Bypass Treatment Planning for Cerebral Ischaemia Based on Multi\u2010Scale Model"],"prefix":"10.1002","volume":"41","author":[{"given":"Suqin","family":"Huang","sequence":"first","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Liu","sequence":"additional","affiliation":[{"name":"National Institute of Metrology, Center for Medical Metrology  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinping","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5012-486X","authenticated-orcid":false,"given":"Fuyou","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University  Shanghai China"},{"name":"World\u2010Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4251-1071","authenticated-orcid":false,"given":"Youjun","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-019-04145-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.11.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201073739\u20103_11"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-012-1412-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opy091"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2022.8.JNS221379"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2022.8.JNS221379"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2022-0211"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-023-02257-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23662"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/acca5d"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2351031799"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-14-S1-S10"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626155"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.10.JNS191207"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107222"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32643-z"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2019.04.032"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.107034"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1085871"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-020-10092-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3465"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.663668"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-020-02519-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.07.022"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-022-05455-9"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2024.03.128"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3828"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3532"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009996"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-009-0449-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-33-4709-0_20"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-15923-8_8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-10-84"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actaastro.2023.06.018"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2204150"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(73)90099-7"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(73)90012-2"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15617952"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-022-01484-5"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11040511"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.10.6.711"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.61"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-011-0331-8"},{"key":"e_1_2_11_47_1","first-page":"1770","article-title":"Relationship Between Variations in the Circle of Willis and Flow Rates in Internal Carotid and Basilar Arteries Determined by Means of Magnetic Resonance Imaging With Semiautomated Lumen Segmentation: Reference Data From 125 Healthy Volunteers","volume":"27","author":"Tanaka H.","year":"2006","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X241226483"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.734311"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2020.113030"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3639"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1544-8"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107718"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T15:21:22Z","timestamp":1753716082000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.70026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cnm.70026"],"URL":"https:\/\/doi.org\/10.1002\/cnm.70026","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70026"}}