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This study uses a novel modelling approach to generate finite element models to examine the influence of subject\u2010specificity in the treatment of distal femur fractures. Three subject\u2010specific finite element models are created from clinical CT scans, and the proposed approach is employed to impose identical fractures and locking plate treatments upon them. Additionally, the performance of the generic two\u2010material model based on a Sawbones fourth generation femur is also evaluated. Interfragmentary motions, plate stresses, and strains at the screw\u2010bone interface are examined due to a physiological loading at different stages of healing. The study finds that subject\u2010specificity has a major effect on strains in the bone at the screw\u2010bone interface. However, interfragmentary motions at the far cortex and plate stresses show minimal sensitivity to subject\u2010specific factors, while near\u2010cortical and shear interfragmentary motions are influenced by them. The influence of subject\u2010specificity decreases as healing progresses. These results indicate that while generic approaches may be sufficient to calculate global assembly responses, material heterogeneity and subject\u2010specific bone stock variations have a large impact on the interaction between the screws and bone. The study also shows that the proposed method, which enables manipulating bone geometry while retaining subject\u2010specific properties, can be used to evaluate the influence of subject\u2010specificity for other orthopaedic simulations.<\/jats:p>","DOI":"10.1002\/cnm.70043","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T14:18:07Z","timestamp":1747664287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Comparison of Generic and Subject\u2010Specific Finite Element Models of Distal Femur Fractures Treated With Locking Plates"],"prefix":"10.1002","volume":"41","author":[{"given":"Gareth","family":"Buhl","sequence":"first","affiliation":[{"name":"Institute for Bioengineering School of Engineering, The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-3909","authenticated-orcid":false,"given":"Pankaj","family":"Pankaj","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering School of Engineering, The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2006.04.130"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u2010799X\u20108\u201043"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.09.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2014.974580"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.11138\/ccmbm\/2015.12.3s.054"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/22071.8759"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.06.044"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105413.80043"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2002.34817"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2013.03.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010012\u20101529\u20102"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635\u2010200910000\u201000007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447\u201320120725\u201021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736\u20100266(02)00044\u2010X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24286"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23193"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010010\u20100196\u2010y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101395385"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2536"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020\u20101383(18)30296\u20101"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-824481-4.00033-0"},{"key":"e_1_2_10_23_1","unstructured":"AO\u2010Surgical Reference \u201cT. 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