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In this study, a physiology\u2010based computational model of the cerebral circulation was developed to yield a tool for generating large\u2010scale in silico data to characterize the changes of the dpPR of the left internal CAS in response to variations in SR and various anatomical\/pathophysiological factors that represent inter\u2010patient differences. In addition, a cerebral ischemia index (CII) was defined to evaluate the predictive value of dpPR for cerebral ischemia. Results showed that dpPR was affected by many factors unrelated to the severity of stenosis, such as the anatomical structure and geometrical size of cerebral arteries, mean systemic arterial blood pressure (MAP), flow autoregulation function of cerebral microcirculation (quantified by CFAI), and coexisting contralateral CAS. In comparison with SR, dpPR exhibited a stronger correlation with CII. In particular, the relationship between dpPR and CII was found to be describable by a mathematical function if MAP and CFAI were fixed. The findings not only deepen our understanding of the physiological implications of dpPR but also provide valuable theoretical insights to guide the application of dpPR in clinical practice.<\/jats:p>","DOI":"10.1002\/cnm.70044","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T04:19:33Z","timestamp":1746591573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Computational Model\u2010Based Study on Trans\u2010Stenotic Pressure Ratio of Carotid Artery Stenosis and Its Predictive Value for Cerebral Ischemia"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0707-0805","authenticated-orcid":false,"given":"Yingjie","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Engineering Mechanics, School of Ocean and Civil Engineering Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurovascular Intervention, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurovascular Intervention, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5012-486X","authenticated-orcid":false,"given":"Fuyou","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics, School of Ocean and Civil Engineering Shanghai Jiao Tong University  Shanghai China"},{"name":"Key Laboratory of Hydrodynamics (MOE), School of Ocean and Civil Engineering Shanghai Jiao Tong University  Shanghai China"},{"name":"Institute for Computer Science and Mathematical Modeling Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863x14557722"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2214\u2010109x(20)30117\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.532218"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.1.Jns142452"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341410"},{"issue":"3","key":"e_1_2_10_7_1","article-title":"Diagnosis and Treatment of Carotid Artery Stenosis","volume":"7","author":"Radic B.","year":"2017","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00252\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2292030516"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2019.01.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(19)30035\u20103"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.04.073"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.01.037"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.4835"},{"issue":"8","key":"e_1_2_10_15_1","first-page":"1025","article-title":"Which Is a Better Treatment for Carotid Artery Stenosis: Stenting or Endarterectomy?","volume":"17","author":"Burgazli K. 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