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The presence of moving fluids significantly influences the mechanical and biological responses of the skin, affecting its time\u2010dependent behavior and the transport of essential nutrients and oxygen to cells. Poroelastic modeling emerges as a promising approach to investigate biologically relevant phenomena at finer scales while embedding crucial mechanisms at larger scales as it facilitates the integration of multi\u2010scale and multi\u2010physics processes. Despite extensive use of poromechanics in other tissues, no hierarchical multi\u2010compartment porous model that incorporates blood supply has yet been experimentally evaluated to simulate the in\u00a0vivo mechanical and micro\u2010circulatory response of human skin. This paper introduces a hierarchical two\u2010compartment model that accounts for fluid distribution within the interstitium and the micro\u2010circulation of blood. A general theoretical framework, which includes a biphasic interstitium (comprising interstitial fluid and non\u2010structural cells), is formulated and studied through a one\u2010dimensional consolidation test of a 100\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    m column. The inclusion of a biphasic interstitium allows the model to account separately for the motion of cells and interstitial fluid, recognising their differing characteristic times. An extension of the model to include biological exchanges such as oxygen transport is discussed in the appendix. The preliminary evaluation demonstrated that cell viscosity introduces a second characteristic time beyond that of interstitial fluid movement. However, at high cell viscosity values and short time scales, cells exhibit behavior akin to that of solid materials. Based on these observations, a simplified version of the model was used to replicate an experimental campaign carried out on short time scales. Local pressure (up to 31\u2009kPa) was applied to the skin of the dorsal face of the middle finger through a laser Doppler probe PF801 (Perimed Sweden) attached to an apparatus as previously described (Fromy Brain Res 1998). The model demonstrated its qualitative ability to represent both ischaemia and post\u2010occlusive reactive hyperaemia, aligning with experimental observations. All numerical simulations were performed using the open source software FEniCSx v0.9.0. To promote transparency and reproducibility, the anonymized experimental data and the corresponding finite element codes are publicly available on GitHub.\n                  <\/jats:p>","DOI":"10.1002\/cnm.70066","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T08:28:57Z","timestamp":1752308937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hierarchical Poromechanical Approach to Investigate the Impact of Mechanical Loading on Human Skin Micro\u2010Circulation"],"prefix":"10.1002","volume":"41","author":[{"given":"Thomas","family":"Lavigne","sequence":"first","affiliation":[{"name":"Institute of Computational Engineering, Department of Engineering University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"},{"name":"Institut de Biom\u00e9canique Humaine Georges Charpak, Arts et M\u00e9tiers Institute of Technology  Paris France"},{"name":"CNRS, Bordeaux INP, I2M, UMR 5295, I2M Bordeaux, Arts et Metiers Institute of Technology, University of Bordeaux  Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Urcun","sequence":"additional","affiliation":[{"name":"Institute of Computational Engineering, Department of Engineering University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-0334","authenticated-orcid":false,"given":"B\u00e9reng\u00e8re","family":"Fromy","sequence":"additional","affiliation":[{"name":"CNRS UMR 5305, Tissue Biology and Therapeutic Engineering Laboratory (LBTI)  Lyon France"},{"name":"Claude Bernard University Lyon  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Josset\u2010Lamaugarny","sequence":"additional","affiliation":[{"name":"CNRS UMR 5305, Tissue Biology and Therapeutic Engineering Laboratory (LBTI)  Lyon France"},{"name":"Claude Bernard University Lyon  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lagache","sequence":"additional","affiliation":[{"name":"Institut de Biom\u00e9canique Humaine Georges Charpak, Arts et M\u00e9tiers Institute of Technology  Paris France"},{"name":"CNRS, Bordeaux INP, I2M, UMR 5295, I2M Bordeaux, Arts et Metiers Institute of Technology, University of Bordeaux  Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo A.","family":"Suarez\u2010Afanador","sequence":"additional","affiliation":[{"name":"Institute of Computational Engineering, Department of Engineering University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane P. 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