{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:54:20Z","timestamp":1791320060943,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR56212"],"award-info":[{"award-number":["R01AR56212"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018283","name":"Fifth District Eagles Cancer Telethon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K25AG068368"],"award-info":[{"award-number":["K25AG068368"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007518","name":"North Dakota State University Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007518","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Accurately predicting vertebral fracture risk in metastatic spines remains a critical challenge in clinical practice. This study developed and validated a QCT\u2010based finite element analysis (QCT\/FEA) approach to investigate the combined effects of baseline bone strength and tumor size on vertebral structural integrity. Areal bone mineral density (aBMD) was also calculated from QCT data to evaluate the reduction in bone density with increasing defect size. Nine cadaveric vertebral bodies were analyzed under varying tumor sizes (0%, 20%, 35%, and 50%). The results demonstrated a strong correlation between experimentally measured and computationally predicted failure forces (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and aBMD values (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.96,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Vertebral strength decreased linearly with increasing tumor size. Importantly, the study revealed that baseline vertebral strength plays a crucial role in fracture risk assessment, often surpassing the impact of tumor size alone. Tumor size reduced vertebral strength at a rate 84% faster than bone density (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009), highlighting a greater impact of tumor defects on bone fracture force than on bone density. These findings suggest that relying solely on tumor size for fracture risk prediction may be insufficient. Incorporating baseline bone strength into predictive models significantly enhances accuracy and reliability, providing valuable insights for clinical decision\u2010making and personalized treatment strategies. This study underscores the importance of advanced computational tools in improving vertebral fracture risk assessment in metastatic spine cases.\n                  <\/jats:p>","DOI":"10.1002\/cnm.70081","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T10:28:24Z","timestamp":1754908104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Computational Assessment of Fracture Risk in Vertebral Bodies With Simulated Defects: The Role of Baseline Strength and Tumor Size"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0195-9843","authenticated-orcid":false,"given":"Mehran","family":"Fereydoonpour","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering North Dakota State University  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areonna","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-6493","authenticated-orcid":false,"given":"Lichun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Ziejewski","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering North Dakota State University  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghodrat","family":"Karami","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering North Dakota State University  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.3.1047"},{"key":"e_1_2_11_3_1","article-title":"Epidemiology and Clinic of Vertebral Mestastasis","volume":"67","author":"G\u00f3mez J. 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