{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:01:20Z","timestamp":1793314880643,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>An experimental and numerical investigation of the blood flow across the stenosis embedded in the elastic artery had been carried out within a framework of a project aimed at the development of the decision support system for the diagnostics of stable coronary artery disease, using a novel hybrid physics\u2010informed machine learning (ML) and computational fluid dynamics (CFD) approach. Integration of CFD equations into a ML framework requires the development and validation of a CFD model optimized for this specific task. The values of empirical coefficients required for the implementation of the CFD component of the project were obtained by collecting experimental data on a pressure drop in elastic arterial models with stenoses in the physiologically relevant range of flow conditions, and the results were used for the validation of the numerical solver. Analysis of the experimental data also demonstrated a strong impact of the vessels' elasticity on the pressure drop across a stenosis, as well as a substantial role of the time\u2010dependent (pulsative) flow parameters. It has been shown that fine\u2010tuning of the values of the viscous and turbulent resistance coefficients to account for the elasticity of the vessels surrounding the stenosis can substantially improve the accuracy of the pressure drop prediction in the intermediate lesions, specifically relevant for clinical applications.<\/jats:p>","DOI":"10.1002\/cnm.70099","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:10:06Z","timestamp":1758618606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of the Pressure Drop in Arterial Models With Stenoses Using Numerical and Experimental In\u00a0Vitro Approaches: Effect of Elasticity"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3344-0553","authenticated-orcid":false,"given":"B.","family":"Chernyavsky","sequence":"first","affiliation":[{"name":"BioME Science  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mouzali","sequence":"additional","affiliation":[{"name":"Dauphine PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Glanz","sequence":"additional","affiliation":[{"name":"BioME Science  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Velikorodny","sequence":"additional","affiliation":[{"name":"BioME Science  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Coronary Pressure","author":"Pijls N. H. J.","year":"1999"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.083"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.08.024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.03.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","unstructured":"L.Itu P.Sharma V.Mihalef A.Kamen C.Suciu andD.Lomaniciu \u201cA Patient\u2010Specific Reduced\u2010Order Model for Coronary Circulation \u201d in 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI) Barcelona Spain (2012):832\u2013835 https:\/\/doi.org\/10.1109\/ISBI.2012.6235677.","DOI":"10.1109\/ISBI.2012.6235677"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35344-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2908"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-018-00388-w"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2017.11.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002693"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5223-z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez160"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00752.2015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/tkde.2021.3079836"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2015.08.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2445777"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2018.10.045"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4741"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003143376-15"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2019.112623"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2003.812201"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(73)90099-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(73)90012-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(76)90086-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109290(84)90123\u20104"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4005472"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.1.99"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:ENGI.0000007979.32871.e2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:ENGI.0000007980.01347.29"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1326031"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1051\/epjap:2000213"},{"key":"e_1_2_9_33_1","first-page":"145","article-title":"A Wave Propagation Model of Blood Flow in Large Vessels Using an Approximate Velocity Profile Function","volume":"80","author":"Bessems D.","year":"2001","journal-title":"Journal of Fluid Mechanics"},{"key":"e_1_2_9_34_1","first-page":"564","volume-title":"Mcdonald's Blood Flow in Arteries","author":"Nichols W. W.","year":"1998"},{"key":"e_1_2_9_35_1","first-page":"227","volume-title":"Mathematical Biofluiddynamics","author":"Lighthill J.","year":"1989"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1088\/0143-0815\/12\/1\/003"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517\u2010008\u20100359\u20102"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(92)90060-E"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2019.05.030"},{"key":"e_1_2_9_40_1","volume-title":"Computer Methods, Imaging and Visualization in Biomechanics and Biomedical Engineering. CMBBE 2019. Lecture Notes in Computational Vision and Biomechanics, Vol 36","author":"Ventre J.","year":"2019"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258047"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0715-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2514\/2.6901"},{"key":"e_1_2_9_44_1","unstructured":"B.ChernyavskyandA.Velikorodny \u201cDevelopment and Validation of Numerical Blood Flow Model Providing Medical Decision Support for the Management of Patients With Coronary Artery Disease \u201d paper presented at American Physical Society DFD 2022 Meeting Indianapolis\u2010US November 20\u201322 2022."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4044611"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1500407"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00348-013-1528-0"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:13:08Z","timestamp":1758885188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.70099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cnm.70099"],"URL":"https:\/\/doi.org\/10.1002\/cnm.70099","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70099"}}