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Compression therapy is one of the main treatments for lymphedema, but its effects on lymphedematous soft tissues are not yet fully understood. In this study, we developed a finite element model of a lymphedematous leg including subcutaneous and muscle tissues, as well as skin and fascia cruris, to investigate the hydrostatic pressure distribution resulting from the interface pressure applied by a compression stocking. The results highlight the significant influence of the leg's external geometry on the interface pressure, and demonstrate the importance of modeling skin to accurately predict hydrostatic pressure distribution in the subcutaneous tissue, with a 3.5% reduction in leg volume observed after compression. The outcomes improve the understanding of the effects of compression therapy on lower limbs affected by lymphedema and support the development of adapted treatment strategies for patients.<\/jats:p>","DOI":"10.1002\/cnm.70123","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T01:50:12Z","timestamp":1765245012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Finite Element Modeling of Compression Therapy in Lower Limb Lymphedema"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5350-3715","authenticated-orcid":false,"given":"Mateus Am\u00e9rico","family":"de Almeida","sequence":"first","affiliation":[{"name":"Mines Saint\u2010Etienne, INSERM, U1059 Sainbiose  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aratz","family":"Garc\u00eda\u2010Llona","sequence":"additional","affiliation":[{"name":"Mines Saint\u2010Etienne, INSERM, U1059 Sainbiose  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Reda","sequence":"additional","affiliation":[{"name":"Mines Saint\u2010Etienne, INSERM, U1059 Sainbiose  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-7736","authenticated-orcid":false,"given":"St\u00e9phane","family":"Avril","sequence":"additional","affiliation":[{"name":"Mines Saint\u2010Etienne, INSERM, U1059 Sainbiose  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.116"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318213a218"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.975002"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010fluid\u2010122316\u2010045259"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000257149.42922.7e"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5152\/turkjsurg.2017.3870"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3400\/avd.ra.24\u201000011"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010014\u20103518\u20108"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010013\u20101879\u20103"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.06.004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1531003509337155"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58070954"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677\u20105449.190074"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2023.24.7.2225"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.924071"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.16121"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.04.031"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nme.6515"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2011.560666"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2013.815955"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010014\u20101121\u20106"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010017\u20101929\u2010y"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2018.12.021"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12424"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13087"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517\u2010017\u20101615\u20100"},{"issue":"3","key":"e_1_2_12_28_1","first-page":"123","article-title":"Where Do Lymph and Tissue Fluid Accumulate in Lymphedema of the Lower Limbs Caused by Obliteration of Lymphatic Collectors?","volume":"42","author":"Olszewski W. 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