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This disease is prominent in patients with hypoplastic left heart syndrome (HLHS). Although HLHS patients typically survive into adulthood, they have reduced cardiac output due to their univentricular physiology (i.e., a Fontan circuit). As a result, they have insufficient blood delivery to the liver. In comparison, patients with double outlet right ventricle (DORV), also having a univentricular circuit, have a lower incidence of FALD. In this study, we use a patient\u2010specific, one\u2010dimensional computational fluid dynamics (1D\u2010CFD) model to predict hemodynamics in the liver of an HLHS patient and compare the predictions with an age\u2010 and size\u2010matched single\u2010ventricle Fontan DORV control patient. Additionally, we simulate FALD conditions in the HLHS patient to predict hemodynamic changes across various stages of disease progression. Our results show that the HLHS patient has higher hepatic arterial pressure compared to the DORV patient. This difference is exacerbated as FALD conditions progress. HLHS patients also have higher average portal pressures than DORV patients. The wall shear stress (WSS) is higher in the hepatic network for the simulated FALD patients. WSS is slightly decreased in the portal network for the HLHS patients, consistent with the development of portal hypertension. Perfusion analysis gives insight into regions of liver tissue at risk for fibrosis development, showing increasing pressures and reduced flow throughout the liver tissue fed by the portal vein under FALD conditions. Our results provide insight into the specific hemodynamic changes in Fontan circulation that can cause FALD.<\/jats:p>","DOI":"10.1002\/cnm.70128","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T04:31:24Z","timestamp":1768192284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A One\u2010Dimensional (\n                    <scp>1D<\/scp>\n                    ) Computational Fluid Dynamics Study of Fontan\u2010Associated Liver Disease (\n                    <scp>FALD<\/scp>\n                    )"],"prefix":"10.1002","volume":"42","author":[{"given":"Yaqi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Brain and Cognitive Sciences Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Weigand","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Puelz","sequence":"additional","affiliation":[{"name":"Mathematics University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-0044","authenticated-orcid":false,"given":"Mette S.","family":"Olufsen","sequence":"additional","affiliation":[{"name":"Department of Mathematics North Carolina State University  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-9426","authenticated-orcid":false,"given":"Alyssa","family":"Taylor\u2010Lapole","sequence":"additional","affiliation":[{"name":"Computational Applied Mathematics and Operations Research Rice University  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.869671"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.06.026"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20103955(16)30727\u20101"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.8634"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.26.3.240"},{"key":"e_1_2_11_7_1","volume-title":"StatPearls [Internet]","author":"Lee M.","year":"2023"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.738559"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.01.056"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.035"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12570"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.120.045597"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13540"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1100514"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.4199\/C00004ED1V01Y200910ISP001","volume-title":"Hepatic Circulation: Physiology and Pathophysiology","author":"Lautt W. 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