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Stress\u2010based rupture risk estimation using computational biomechanics has been widely studied; however, it requires wall strength data that cannot be measured in humans in\u00a0vivo. To overcome this limitation, the goal of this study is to present a new method for biomechanical assessment of AAA via simultaneous consideration of tension and strain in AAA wall. We present a patient\u2010specific, non\u2010invasive method for assessing the structural integrity of the AAA wall using only time\u2010resolved 3D computed tomography angiography (4D\u2010CTA) images and blood pressure data. The proposed approach integrates wall strain (throughout the cardiac cycle) and wall tension analysis to compute a novel index, the Relative Structural Integrity Index (RSII), which quantifies local wall stiffness independently of wall thickness, wall material properties, and blood pressure measurement conditions. We applied our method to 20 patients from three different hospitals to extract visual RSII maps over the AAA wall of each individual patient and to compare the RSII values between aneurysmal and non\u2010aneurysmal aortas in one patient. Our results primarily show similar RSII values across all patients, indicating the consistency of the method. Additionally, we observed patterns consistent with experimental findings reported in the literature: AAA walls exhibited higher stiffness than healthy aortic walls, while localized low\u2010stiffness zones in the AAA wall were predominantly found in the most dilated regions.<\/jats:p>","DOI":"10.1002\/cnm.70140","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:14:45Z","timestamp":1770131685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Towards Personalised Assessment of Abdominal Aortic Aneurysm Structural Integrity"],"prefix":"10.1002","volume":"42","author":[{"given":"Mostafa","family":"Jamshidian","sequence":"first","affiliation":[{"name":"Intelligent Systems for Medicine Laboratory The University of Western Australia  Perth 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