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Clinicians are expected to assess the rupture risk of AAAs accurately to determine the mode and timing of intervention. In general practice, AAA diameter and growth rate are used as rupture risk indicators. However, numerous cases have been reported where relying solely on these two AAA characteristics has proven insufficient, suggesting that other biomechanical factors deserve further consideration. This paper aims to investigate the involvement of disturbed hemodynamics in AAA rupture. Twenty\u2010two AAA cases that had progressed to the point where surgical intervention was necessitated were assessed to examine the flow dynamics around the rupture sites. Using computational fluid dynamics (CFD), four key wall shear stress (WSS)\u2010related hemodynamic parameters were calculated for each studied case, namely the time\u2010averaged wall shear stress (TAWSS), oscillatory shear index (OSI), endothelial cell activation potential (ECAP), and relative residence time (RRT). CFD geometries were developed exclusively using patient computed tomography images, and simulations were run with general physiological boundary conditions to demonstrate a clinically practical, low\u2010input CFD pipeline. The study found that analyzing the spatial distribution of the WSS\u2010related hemodynamic parameters can be a powerful approach for predicting the site of rupture in AAAs. Low TAWSS and high OSI\/ECAP\/RRT regions (specifically within the ranges: TAWSS 0\u20130.5\u2009Pa, OSI 0.35\u20130.5, ECAP 1.6\u20132.0\u2009Pa\n                    <jats:sup>\u22121<\/jats:sup>\n                    , RRT 24\u201330) were found to be high\u2010risk locations for rupture. Additionally, the simultaneous analysis of all four parameters was critical for rupture risk assessment.\n                  <\/jats:p>","DOI":"10.1002\/cnm.70153","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:46:53Z","timestamp":1774010813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated Assessment of Wall Shear Stress\u2010Related Hemodynamic Parameters in Abdominal Aortic Aneurysms: A Retrospective Cross\u2010Sectional Study on\u00a0Ruptured Cases"],"prefix":"10.1002","volume":"42","author":[{"given":"Onur","family":"Mutlu","sequence":"first","affiliation":[{"name":"Biomedical Research Center, QU Health Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahib A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, QU Health Qatar University  Doha Qatar"},{"name":"Department of Mechanical and Industrial Engineering, College of Engineering Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-9902","authenticated-orcid":false,"given":"Huseyin E.","family":"Salman","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering TOBB University of Economics and Technology  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"El\u2010Menyar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Trauma and Vascular Surgery, Hamad General Hospital, Hamad Medical Corporation  Doha Qatar"},{"name":"Clinical Medicine Weill Cornell Medicine  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-4115","authenticated-orcid":false,"given":"Mehmet M.","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Middle East Technical University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-8206","authenticated-orcid":false,"given":"Muhammad E. 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