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Biodegradable metallic 3D\u2010printed scaffolds are promising for orthopedic applications due to their ability to provide sufficient mechanical support while gradually degrading and supporting bone healing. This study investigates the mechanical and fluid transport properties of Fe\u201310Mn\u20131Pd scaffolds for femoral fracture repair. The performance of 10 different lattice structures was first evaluated using finite element modeling (FEM) and validated by experimental compression testing, identifying the parallel face\u2010centered cubic (PFCC) scaffold as optimal due to its superior stiffness\u2010to\u2010weight ratio. 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These findings confirm that the PFCC Fe\u201310Mn\u20131Pd scaffold, combined with a magnesium\u2010based fixation mechanism, provides both mechanical support and fluid transmission.<\/jats:p>","DOI":"10.1002\/cnm.70175","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:50:14Z","timestamp":1776844214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Finite Element and Computational Fluid Dynamics Analysis of a Biodegradable Implant for Large Femoral Bone Defects"],"prefix":"10.1002","volume":"42","author":[{"given":"Sina","family":"Taghipour","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering University of Tabriz  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Vakili\u2010Tahami","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Tabriz  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108630"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings12060839"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma8095273"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS\u2010D\u201014\u201000018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2019.06.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.111003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01329"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-35876-1_9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13030104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.22038\/abjs.2018.26340.1713"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2020.02.457"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.05.017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1091294"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmapro.2023.02.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.12.267"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.36922\/ijb.1698"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.202301260"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/computation12040074"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.109832"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.03.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/729076"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2024.2305227"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020325"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102130"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rineng.2024.101883"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.37934\/cfdl.15.7.6173"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758\u20105090\/aba412"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237\u2010019\u201001188\u20104"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compstruct.2023.117256"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00107"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.995266"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.32604\/cmes.2025.057675"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247764"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.980727"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jma.2021.08.017"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.07.005"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jma.2021.03.004"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","unstructured":"V.BadishaandR. 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