{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:55:06Z","timestamp":1790567706756,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["CEX2021\u2010001142S\/MICIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["CEX2021\u2010001142S\/MICIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Blood coagulation is governed by tightly regulated reaction networks whose activation and early evolution are influenced by transport processes. While reduced kinetic models of the intrinsic and extrinsic pathways have been validated in well\u2010mixed experimental settings, their behavior in spatially resolved domains remains insufficiently characterized. In this work, two established reduced coagulation networks are embedded within a thermodynamically consistent mesoscale particle\u2010based framework that resolves fluid momentum transport together with multispecies advection\u2013diffusion\u2013reaction dynamics. Unlike conventional continuum coagulation solvers, the proposed formulation captures coupled transport and biochemical interactions through interacting particles within a unified hydrodynamic description. The framework is used to investigate the initiation phase of coagulation under controlled microvascular\u2010like flow conditions in simplified channel geometries. The simulations reproduce characteristic thrombin generation curves (TGCs) across physiologically relevant parameter ranges while additionally revealing spatial transport effects that are not captured by outlet\u2010averaged measures alone. In particular, the results show that transport\u2013reaction coupling induces pronounced spatial heterogeneities in thrombin concentration, with transitions between localized activation, wall\u2010aligned accumulation, and advective washout depending on Reynolds and P\u00e9clet regimes. Injury geometry is further shown to modulate coagulation amplification, with capped configurations producing enhanced thrombin accumulation due to localized surface\u2010mediated activation. Complementary quiescent\u2010domain simulations additionally reproduce qualitative trends observed in thrombodynamics assays, including fibrinogen\u2010dependent variations in fibrin formation. Overall, the study introduces a unified mesoscale computational framework for analyzing how flow, transport, and biochemical kinetics jointly regulate early coagulation dynamics in spatially resolved domains.<\/jats:p>","DOI":"10.1002\/cnm.70212","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:12:42Z","timestamp":1789621962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesoscale Simulations of Blood Coagulation in Flow and Quiescent Domains Using\n                    <scp>SDPD<\/scp>"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7076-3052","authenticated-orcid":false,"given":"Marina Echeverr\u00eda","family":"Ferrero","sequence":"first","affiliation":[{"name":"Basque Center for Applied Mathematics  Bilbao Bizkaia Spain"},{"name":"University of the Basque Country UPV\/EHU  Leioa Bizkaia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Moreno","sequence":"additional","affiliation":[{"name":"Basque Center for Applied Mathematics  Bilbao Bizkaia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ellero","sequence":"additional","affiliation":[{"name":"Basque Center for Applied Mathematics  Bilbao Bizkaia Spain"},{"name":"IKERBASQUE, Basque Foundation for Science  Bilbao Bizkaia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615947"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021868"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13280"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00107a001"},{"key":"e_1_2_12_6_1","unstructured":"National Library of Medicine (US) Pubmed. Search: \u201cCoagulation Computational \u201d(2025) https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=coagulation+computational&filter=years.1970\u20102025."},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089930"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2007.06.030"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10273660412331317415"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000950"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1722861"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/b812429a"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201173200"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.32.22862"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)76085-7"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-0822-4_7"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plrev.2018.02.005"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apples.2022.100103"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3698"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/imammb\/dqq005"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089931"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000229658.76797.30"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388140"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-025-01944-9"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007266"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-021-00890-8"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3652"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3220"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-018-1033-8"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-017-0983-6"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-020-01411-7"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0281424"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compfluid.2019.03.021"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-019-01262-x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009850"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009892"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102570"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4923254"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.03.009"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/17486700701852784"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3731"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.67.026705"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3058437"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SM01090B"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SM01126K"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-013-0497-9"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0295983"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071636"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69415-y"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.68.041504"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1086\/112164"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3050100"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4942499"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15143"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1293809"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.fluid.37.042604.133933"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2021.108171"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/jfm.2023.540"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13241"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.12.055"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2015.04.044"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58753"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-016-0469-0"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86310-2"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.08.004"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2850"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0290-8"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.08.014"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020201"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-fluid-010814-014513"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2026.110122"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10483-018-2255-6"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471727903"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.1999.6237"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.1997.5776"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661576"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2021.110915"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201700070"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.109.108102"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-016-0470-7"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10441-019-09372-w"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44663-1"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnm.70212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:57:16Z","timestamp":1790564236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.70212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cnm.70212"],"URL":"https:\/\/doi.org\/10.1002\/cnm.70212","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70212"}}