{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:51:17Z","timestamp":1791359477761,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL160997"],"award-info":[{"award-number":["HL160997"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2222066"],"award-info":[{"award-number":["2222066"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We present a computational modeling framework coupling a poroelastic left ventricle (LV) with lumped\u2010parameter descriptions of the coronary and systemic circulations in a closed\u2010loop system. The finite element method, with P1\u2010P1\u2010P0 discretization of the displacement, Darcy flow and pore\u2010pressure fields, is used to solve the boundary value problem associated with the poroelastic formulation. We show that simulation of the isolated non\u2010contractile poroelastic LV can reproduce perfusion\u2010induced stiffening features found in measurements of pressure\u2010volume relationships with less than 1\u2009mmHg error. Simulations coupling the poroelastic LV with systemic and coronary circulatory models also show that the framework can produce phasic changes in coronary flow rate and myocardial wall volume that agree with the experiments. Using the framework, we investigate the effects of coronary sinus (CS) resistance on myocardial perfusion. We show that increasing CS resistance attenuates coronary flow rate, increases myocardial pore pressure, and promotes myocardial swelling.<\/jats:p>","DOI":"10.1002\/cnm.70219","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:38Z","timestamp":1791356858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Poroelastic Computational Modeling Framework Coupling Left Ventricular Cardiac Mechanics and Myocardial Perfusion"],"prefix":"10.1002","volume":"42","author":[{"given":"Haowei","family":"An","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Ziaei\u2010Rad","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-6428","authenticated-orcid":false,"given":"Lik\u2010Chuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00789439","article-title":"Mechanical Determinants of Myocardial Perfusion","volume":"90","author":"Spaan J. 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Heart and Circulatory Physiology"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnm.70219","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:44Z","timestamp":1791356864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.70219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cnm.70219"],"URL":"https:\/\/doi.org\/10.1002\/cnm.70219","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70219"}}