{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:48:23Z","timestamp":1792021703647,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12202041"],"award-info":[{"award-number":["12202041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370493"],"award-info":[{"award-number":["82370493"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The 70%\u201390% mortality rate of ruptured abdominal aortic aneurysms (AAAs) demonstrates the necessity of investigating progression and rupture. The progression and rupture risks of AAAs are influenced by the physiological states of patients, such as exercise and intense emotions. Understanding this association aids in the management of AAAs, but related research remains limited. This study aims to explore the impact of physiological states on progression and rupture risks of AAAs. Different physiological states of a selected AAA patient (characterized by heart rate (HR), stroke volume (SV), blood pressure (BP), pulse pressure (PP), and the rest and exercise conditions) were simulated by altering the inflow and outflow conditions in computational fluid dynamics and in vitro experiments, and hemodynamics were obtained and analyzed. When HR\u2009\u2265\u2009105\u2009bpm, systolic pressure of AAA exceeded 140\u2009mmHg (hypertension). SV\u2009\u2264\u200917\u2009mL induced low time\u2010averaged wall shear stress (TAWSS) (&lt;\u20090.4\u2009Pa) and high oscillatory shear index (OSI) (&gt;\u20090.25); SV\u2009\u2265\u200926\u2009mL induced systolic pressure\u2009\u2265\u2009155\u2009mmHg. Increasing BP from 100\/60 to 140\/100\u2009mmHg and PP from 20 to 60\u2009mmHg, raised the pressure on AAA vascular wall by 53.42% and 15.09%, respectively. Exercise induced higher TAWSS than rest (2.103 vs. 0.644\u2009Pa). These findings rely on a patient\u2010specific model to preliminarily explore the mechanisms and trends of physiological states affecting AAA progression and rupture risks. Large sample studies are needed in the future to validate the conclusions of this study and establish clinical reference risk thresholds.<\/jats:p>","DOI":"10.1002\/cnm.70224","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:05:42Z","timestamp":1792019142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Physiological States on the Progression and Rupture Risks of Abdominal Aortic Aneurysms: A Hemodynamic Study Combining Computational Fluid Dynamics With in Vitro Experiments"],"prefix":"10.1002","volume":"42","author":[{"given":"Yue","family":"Che","sequence":"first","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiran","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Fuwai Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-5080","authenticated-orcid":false,"given":"Xuelan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"},{"name":"Department of Chemical Engineering Imperial College London, South Kensington Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-4655","authenticated-orcid":false,"given":"Chang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Fuwai Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College  Beijing China"},{"name":"Department of Vascular Surgery, Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Fuwai Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College  Beijing China"},{"name":"Department of Vascular Surgery, Central China Subcenter of National Center for Cardiovascular Diseases, Henan Cardiovascular Disease Center, Fuwai Central\u2010China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Vascular Surgery, Fuwai Yunnan Cardiovascular Hospital Affiliated Cardiovascular Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"265","article-title":"An Investigation of Pulsatile Blood Flow in an Angulated Neck of Abdominal Aortic Aneurysm Using Computational Fluid Dynamics","volume":"57","author":"Algabri Y. A.","year":"2019","journal-title":"Journal of Advanced Research in Fluid Mechanics and Thermal Sciences"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13658"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300\u20107073(05)71823\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010019\u201000510\u20109"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13085095"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5812\/iranjradiol.18217"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/19942060.2022.2131628"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.868889"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2023.11.044"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0185094"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2035"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.06.028"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968\u2010022\u201000848\u20102"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.121.013160"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2024.108144"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2023.107963"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0139085"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020192112"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0184229"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00111"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2025.112680"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2022.111422"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742\u20106596\/1600\/1\/012066"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apm.2020.06.066"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10409\u2010025\u201024841\u2010x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3844"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apm.2018.01.029"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3426"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0280903"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15192497"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3793"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10409\u2010025\u201024571\u2010x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10409\u2010024\u201024022\u2010x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239\u2010021\u201000583\u20102"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0234809"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0117879"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.70153"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1690884"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/15266028241285130"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3569"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201034655\u20101"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1179963"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.70033"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnm.70224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.70224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:05:44Z","timestamp":1792019144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.70224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cnm.70224"],"URL":"https:\/\/doi.org\/10.1002\/cnm.70224","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70224"}}