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These infections arise primarily from the absence of a stable epithelial seal at the implant\u2013skin interface, permitting bacterial colonization of the stoma, particularly by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ). Fluorapatite (FAp) coatings have previously demonstrated potential to enhance epithelial integration, yet additional antimicrobial functionality could limit bacterial colonization on the device. This study investigated metal doping as a strategy to create dual\u2010functional FAp surfaces that resist bacterial adhesion for percutaneous OI applications. Zinc\u2010, copper\u2010, and silver\u2010doped FAp were synthesized in\u2010house using a validated precipitation method and comprehensively characterized. Sintered discs were evaluated for\n                    <jats:italic>S. aureus<\/jats:italic>\n                    adhesion and cytocompatibility to keratinocytes. Fourier transform infrared confirmed retention of the hexagonal apatite structure across all doping compositions. X\u2010ray diffraction revealed secondary phases at higher dopant levels. SEM showed dopant\u2010dependent microstructural changes. Only copper\u2010doped FAp (1%\u20135%) reduced\n                    <jats:italic>S. aureus<\/jats:italic>\n                    adhesion by &gt;3 log\u2010folds. However, copper\u2010doped surfaces exhibited reduced cytocompatibility to keratinocytes, highlighting a trade\u2010off between anti\u2010bacterial adhesion efficacy and epithelial attachment affinities. These findings indicate that lower copper doping levels warrant further investigation to achieve keratinocytes adhesion for percutaneous implant coating applications.\n                  <\/jats:p>","DOI":"10.1002\/cnma.202500276","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:27:21Z","timestamp":1774852041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Zinc\u2010, Copper\u2010, and Silver\u2010Doped Fluorapatite as Bacteriophobic Surfaces for Percutaneous Osseointegrated Device Applications"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2199-7191","authenticated-orcid":false,"given":"Sujee","family":"Jeyapalina","sequence":"first","affiliation":[{"name":"Plastic and Orthopaedic Surgery Research Laboratory George E. 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