{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:43:22Z","timestamp":1773243802805,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tasmania is a large, relatively isolated island located south of mainland Australia with limited tertiary level paediatric oncology services.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To benchmark regional outcomes for childhood acute lymphoblastic leukaemia (ALL) against published international standards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a retrospective cohort study, analysing the clinical characteristics and health outcomes of all children diagnosed with and treated for ALL in Tasmania, Australia between 2006 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five patients aged less than 18\u00a0years were diagnosed with ALL in the study's 10\u2010year period. Twenty\u2010eight cases were precursor B cell in origin, with 7 cases of T\u2010cell ALL. The great majority of children (30\/35; 86%) received their entire first line treatment in Tasmania. Major treatment\u2010related toxicities, including allergic drug reactions, and episodes of acute pancreatitis, deep venous thrombosis and bacterial sepsis, were managed locally, with one death secondary to overwhelming infection and multiorgan failure. The overall and event\u2010free survival rates for childhood ALL were 30\/35 (86%) and 28\/35 (80%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results compare favourably with published results from large international cooperative group trials based in developed countries. Continued local treatment with appropriate support from a dedicated specialist paediatric oncology unit is therefore justified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1107","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T14:20:16Z","timestamp":1528122016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Favourable outcomes for childhood acute lymphoblastic leukaemia in an isolated setting: The Tasmanian experience"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-0669","authenticated-orcid":false,"given":"John A.","family":"Heath","sequence":"first","affiliation":[{"name":"Department of Paediatrics Royal Hobart Hospital  Hobart Tasmania Australia"},{"name":"Department of Medicine University of Tasmania  Hobart Tasmania 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