{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:25:33Z","timestamp":1768436733656,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The cortico\u2010ponto\u2010cerebellar tract (CPCT) is the largest projection pathway, which synapses at the pons. Remote effects of supratentorial brain tumors have not been evaluated along the infratentorial course of the CPCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study is to evaluate the possible lateralization of the diffusion tensor metrics of the affected CPCT in patients with supratentorial brain tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We included 39 patients with 29 left\u2010sided tumors (LST) and 10 right\u2010sided tumors, retrospectively. We measured the magnitude of changes of the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the CPCT prior to the brain surgery at the level of crus cerebri and middle cerebellar peduncle. Regions of interest (ROIs) were placed on the lateral side of crus cerebri, and ROI\u20101 (anterior 1\/3), ROI\u20102 (middle 1\/3), ROI\u20103 (posterior 1\/3), and ROI\u20104 were placed at the level of middle cerebellar peduncle. We hypothesized that there would be decreased FA and increased ADC values of the ipsilesional CPCT compared with contralesional CPCT.<\/jats:p><jats:p>Ipsilesional FA values were decreased with simultaneous increased ADC value along the CPCT compared with contralesional CPCT in following ROIs, ROI\u20101 (LST FA: <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005, ADC: <jats:italic>P<\/jats:italic>\u00a0=\u00a0.037) and ROI\u20103 (LST FA: <jats:italic>P<\/jats:italic>\u00a0=\u00a0.049, ADC: <jats:italic>P<\/jats:italic>\u00a0=\u00a0.049), respectively. Affected ROI\u20104 in LST cases also showed lower FA values, although not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a statistically significant FA value decrease and ADC increase along the left ROI\u20101 and ROI\u20103 as well as the nonstatistically significant FA decrease of the left ROI\u20104 at the second neuron level when there was a related supratentorial tumor. These findings are suggestive of presynaptic and postsynaptic microstructural changes of these tracts following the presynaptic involvement by a primary supratentorial brain tumor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1108","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T11:20:22Z","timestamp":1531308022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative assessment of changes in diffusion tensor imaging (DTI) metrics along the courses of the cortico\u2010ponto\u2010cerebellar tracts secondary to supratentorial human brain glial tumors"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-7273","authenticated-orcid":false,"given":"Saeedeh","family":"Mirbagheri","sequence":"first","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins University School of Medicine The Johns Hopkins Hospital  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-3247","authenticated-orcid":false,"given":"Arash","family":"Kamali","sequence":"additional","affiliation":[{"name":"Department of Diagnostic &amp; Interventional Imaging, University of Texas Houston Medical School Memorial Hermann Hospital  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Cai","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parastu","family":"Kasaie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Bloomberg School of Public Health The Johns Hopkins University  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay Jan","family":"Pillai","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins University School of Medicine The Johns Hopkins Hospital  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin Krishnakant","family":"Gujar","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins University School of Medicine The Johns Hopkins Hospital  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azita","family":"Khorsandi","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haris Iqbal","family":"Sair","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins University School of Medicine The Johns Hopkins Hospital  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"730","volume-title":"Functional Neuroanatomy. Text and Atlas","author":"Afifi AK","year":"1998"},{"key":"e_1_2_9_3_1","first-page":"650","volume-title":"The Human Brain. 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