{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:17Z","timestamp":1753868657736,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T00:00:00Z","timestamp":1537056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pertuzumab has improved pathologic complete response rates when compared with other chemotherapeutics in the treatment of HER\u20102 positive breast cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We sought to determine if axillary lymph node dissections (ALNDs) yielding at least the national standard of 10 lymph nodes is lower in patients who received neoadjuvant pertuzumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A retrospective database identified patients who underwent ALND for breast cancer. We compared the axillary lymph node retrieval rates in those who received or did not receive neoadjuvant pertuzumab. Of 139 breast cancer patients who underwent ALND, fewer than 10 axillary lymph nodes were found in 41.7% of patients who received neoadjuvant pertuzumab (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and 18.6% of patients who received neoadjuvant therapy without pertuzumab (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neoadjuvant chemotherapy was associated with a significantly lower rate of \u201cadequate\u201d ALNDs as defined by current guidelines. The patient subset that received neoadjuvant pertuzumab was more likely to have fewer than 10 axillary lymph nodes retrieved.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1132","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T04:24:16Z","timestamp":1537158256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A new era of neoadjuvant treatment with Pertuzumab: Should the 10\u2010lymph node guideline for axillary lymph node dissection in breast cancer be revised?"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-4271","authenticated-orcid":false,"given":"Michael P.","family":"O'Leary","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Harbor UCLA Medical Center  Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Beckord","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Harbor UCLA Medical Center  Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle E.","family":"Mock","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Harbor UCLA Medical Center  Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose J.","family":"Venegas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Cytopathology Harbor UCLA Medical Center  Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Harbor UCLA Medical Center  Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Dauphine","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Harbor UCLA Medical Center  Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko J.","family":"Ozao\u2010Choy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Harbor UCLA Medical Center  Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,16]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Comprehensive Cancer Network.Breast Cancer 1.2016.www.nccn.org. Accessed March 2016."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303847"},{"key":"e_1_2_9_4_1","unstructured":"The American Society of Breast Surgeons: Performance and practice guidelines for axillary lymph node dissection in breast cancer patients.https:\/\/www.breastsurgeons.org\/new_layout\/about\/statements\/PDF_Statements\/PerformancePracticeGuidelines_ALND.pdf. Article VII.A. 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