{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:50:54Z","timestamp":1769608254057,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A paraneoplastic syndrome is observed in 5% to 10% of cancer patients. Paraneoplastic vasculitis (PV) in metastatic renal cell carcinoma (mRCC) patients has been poorly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In our case series study, we evaluated the incidence and development of PV in patients with mRCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Patients were required to have previously untreated clear\u2010cell or papillary mRCC and no evidence of autoimmune diseases or venous thrombosis in history. Patients had a careful examination including Doppler ultrasonography of the blood vessels and skin punch biopsy in the presence of suspicious skin rash. Sixteen (8.2%) of 196 patients were diagnosed with PV, which was manifested clinically by leukocytoclastic vasculitis on the lower extremities. Skin biopsy confirmed vasculitis. Progression\u2010free survival and overall survival were significantly better in patients without PV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PV is not rare paraneoplastic syndrome in mRCC. Leukocytoclastic vasculitis was the most common type of PV in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1142","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T09:24:26Z","timestamp":1539681866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Paraneoplastic vasculitis in patients with metastatic renal cell carcinoma"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-0392","authenticated-orcid":false,"given":"Ilya","family":"Tsimafeyeu","sequence":"first","affiliation":[{"name":"Kidney Cancer Research Bureau  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Leonenko","sequence":"additional","affiliation":[{"name":"Stolichnaya Diagnostica Clinic  Tuchkovo Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"Stolichnaya Diagnostica Clinic  Tuchkovo Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Semenkova","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lev","family":"Demidov","sequence":"additional","affiliation":[{"name":"N.N. Blokhin Russian Cancer Research Center  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.31768\/2312-8852.2015.37(2):82-86"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01367.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960501)77:9<1759::AID-CNCR1>3.0.CO;2-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0889-857X(21)00487-7","article-title":"Cutaneous vasculitis","volume":"21","author":"Gibson LE","year":"1998","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3154-4"},{"issue":"10","key":"e_1_2_8_7_1","first-page":"23","article-title":"Use of interleukine\u20102 in a patient with renal cancer and paraneoplastic vasculitis","volume":"76","author":"Demidov LV","year":"2004","journal-title":"Ter Arkh"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1027815"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2848"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","unstructured":"KhochenkovD VolkovaM TsimafeyeuI.Identification of receptor tyrosine kinases (RTKs) expression in tumor\u2010infiltrating lymphocytes (TILs) and peripheral blood mononuclear cells (PBMC) [abstract]. 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