{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:15:48Z","timestamp":1783793748897,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["P30 CA16672"],"award-info":[{"award-number":["P30 CA16672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cancer survivorship has thrown the spotlight on the incidence of nonmalignant chronic diseases in cancer patients. Endothelial injury is increasingly recognized as a consequence of cancer treatment, particularly after radiation therapy (RT). This review is to provide a current understanding on the pathophysiological mechanisms and predictive biomarkers of radiation\u2010induced vascular injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent findings<\/jats:title><jats:p>Radiation directly impacts vasculature by causing endothelial apoptosis and senescence, and alterations in normal homeostasis. This altered milieu at the endothelial surface may contribute to a systemic chronic inflammatory state that is superimposed upon the cascade of normal senescence processes leading to acceleration of age\u2010related disorders, atherosclerosis, and chronic fibrosis. Vasculature imaging, blood\u2010based or cell\u2010component biomarkers, and signatures of genomics, proteomics, metabolomics, and radiomics are potential tools for detection of vascular damage after irradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Development of a valid prediction model by combining an array of imaging tools, blood\u2010based biomarkers, coupled with novel predictors like exosomes and metabolic degradation products can serve to identify RT\u2010induced vascular injury early for subsequent introduction of newer therapeutic approaches to counter radiation morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1152","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T08:23:08Z","timestamp":1543825388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomarkers of radiation\u2010induced vascular injury"],"prefix":"10.1002","volume":"2","author":[{"given":"Bhanu Prasad","family":"Venkatesulu","sequence":"first","affiliation":[{"name":"Departments of Experimental Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Departments of Experimental Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010En","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Departments of Experimental Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"The University of Texas MD Anderson Cancer Center\u2010UT Health Graduate School of Biomedical Sciences  Houston Texas"},{"name":"Departments of Radiation Oncology, Chang Gung Memorial Hospital Linkou and Chang Gung University  Taoyuan Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Experimental Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"The University of Texas MD Anderson Cancer Center\u2010UT Health Graduate School of Biomedical Sciences  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-4771","authenticated-orcid":false,"given":"Sunil","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Departments of Experimental Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"The University of Texas MD Anderson Cancer Center\u2010UT Health Graduate School of Biomedical Sciences  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21324"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00066"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.01.014"},{"key":"e_1_2_11_5_1","article-title":"Arterial stiffness as a biomarker of radiation\u2010induced carotid","author":"Christopher M","year":"2015","journal-title":"Atherosclerosis"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02962-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq033"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-011-0229-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32835856e3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft309"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"343","article-title":"Noninvasive measurements of arterial stiffness: repeatability and interrelationships with endothelial function and arterial morphology measures","volume":"3","author":"Huck CJ","year":"2007","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2015.05.010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002765"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/2008.9.JNS08420"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00026"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310378866"},{"issue":"5","key":"e_1_2_11_17_1","first-page":"3375","article-title":"Irradiation induced expression of CD31, ICAM\u20101 and VCAM\u20101 in human microvascular endothelial cells","volume":"20","author":"Quarmby S","year":"2000","journal-title":"Anticancer Res"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.02.018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120309"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000097001.79750.78"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530000138510"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-4-59"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR1526.1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.041"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480801500206"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04019.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2053"},{"key":"e_1_2_11_28_1","first-page":"5","article-title":"Release and activity of histone in diseases","author":"Chen R","year":"2014","journal-title":"Cell Death & Dis"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2813"},{"issue":"1","key":"e_1_2_11_30_1","article-title":"Differences in circulating endothelial progenitor cells among childhood cancer survivors treated with and without radiation","volume":"1","author":"Pradhan K","year":"2015","journal-title":"J Hematol Thromb"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.03.024"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0436-2"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.03.058"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00303-0"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530096145337"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14406.1"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i26.4701"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2013.763193"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0436-2"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00303-0"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00083-3"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.135155"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40709-017-0059-x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0263"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157616"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrx015"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1009"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.2307\/3578417"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.02.009"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-010-0342-9"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.72.0722"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.615203"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcme.2016.05.001"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124795"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl923"},{"key":"e_1_2_11_56_1","unstructured":"Human metabolome database: About the human metabolome database."},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2003)159[0312:PBFIRE]2.0.CO;2"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707493105"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-013-0372-2"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130388"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcnr2.1152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T04:05:13Z","timestamp":1694318713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/cnr2.1152"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1152","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"assertion":[{"value":"2018-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1152"}}