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PSMA's unique characteristics and its 1000\u2010fold higher expression in PCa compared with other tissues renders it as a suitable biomarker for detection of PCa in its early stage. In this report, we critically analyze and recommend the requirements needed for the development of variety of PSMA\u2010targeted molecular imaging agents based on antibodies, small molecule ligands, peptides, and aptamers. The targeting moieties are either conjugated to radionuclear isotopes or near\u2010infrared agents for efficient diagnosis of PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent findings<\/jats:title>\n                    <jats:p>\n                      From the analysis, it was found that several small molecule\u2013derived PCa imaging agents are approved for clinical trials in Europe and the United States, and few are already in the clinical use for diagnosis of PCa. Even though\n                      <jats:sup>111<\/jats:sup>\n                      In\u2010labeled capromab pendetide was approved by the Food and Drug Administration (FDA) and other engineered antibodies are available for detection of PCa, but high production cost, low shelf life (less than 1\u00a0month at 4\u00b0C), possibility of human immuno reactions, and low blood clearance rate necessitated a need for developing new imaging agents, which are serum stable, cost\u2010effective, and possesses longer shelf life (6\u00a0months), have fast clearance rate from nontargeted tissues during the diagnosis process. It is found that small molecule ligand\u2010derived imaging agents possesses most of the desired properties expected for an ideal diagnostic agent when compared with other targeting moieties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report discusses in detail the homing moieties used in the development of targeted diagnostic tools for detection of PCa. The merits and demerits of monoclonal antibodies, small molecule ligands, peptides, and aptamers for imaging of PCa and intraoperative guided surgery are extensively analyzed. Among all, urea\u2010based ligands were found to be most successful in preclinical and clinical trials and show a major promise for future commercialization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.1169","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T22:23:05Z","timestamp":1554243785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of prostate\u2010specific membrane antigen ligands in clinical translation research for diagnosis of prostate cancer"],"prefix":"10.1002","volume":"2","author":[{"given":"Sagnik","family":"Sengupta","sequence":"first","affiliation":[{"name":"Discipline of Chemistry, School of Basic Sciences Indian Institute of Technology Indore  Indore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mena","family":"Asha Krishnan","sequence":"additional","affiliation":[{"name":"Discipline of Biosciences and Biomedical Engineering, School of Engineering Indian Institute of Technology Indore  Indore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Discipline of Biosciences and Biomedical Engineering, School of Engineering Indian Institute of Technology Indore  Indore India"},{"name":"Discipline of Physics, School of Basic Sciences Indian Institute of Technology Indore  Indore India"},{"name":"Discipline of Metallurgy Engineering and Material Science, School of Engineering Indian Institute of Technology Indore  Indore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-3759","authenticated-orcid":false,"given":"Venkatesh","family":"Chelvam","sequence":"additional","affiliation":[{"name":"Discipline of Chemistry, School of Basic Sciences Indian Institute of Technology Indore  Indore India"},{"name":"Discipline of Biosciences and Biomedical Engineering, School of Engineering Indian Institute of Technology Indore  Indore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2431030580"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0264"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.06.024"},{"key":"e_1_2_10_5_1","unstructured":"Cancer projected to become leading cause of death worldwide in 2010.2008;1\u20135."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22433"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NCC.0000281726.87490.f2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2018.01.012"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"241","article-title":"Prostate\u2010specific membrane antigen as a target for cancer imaging and therapy","volume":"59","author":"Kiess AP","year":"2015","journal-title":"J Nucl Med Mol Imaging"},{"key":"e_1_2_10_11_1","first-page":"1","article-title":"Targeting prostate cancer: prostate\u2010specific membrane antigen based diagnosis and therapy","volume":"39","author":"W\u00fcstemann T","year":"2018","journal-title":"Med. 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