{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:21:52Z","timestamp":1764350512524,"version":"3.41.2"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myeloid leukemia represents a heterogeneous group of cancers of blood and bone marrow which arise from clonal expansion of hematopoietic myeloid lineage cells. Acute myeloid leukemia (AML) has traditionally been treated with multi\u2010agent chemotherapy, but conventional therapies have not improved the long\u2010term survival for decades. Chronic myeloid leukemia (CML) is an indolent disease which requires lifelong treatment, is associated with significant side effects, and carries a risk of progression to potentially lethal blast crises.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent Findings<\/jats:title><jats:p>Recent advances in molecular biology, virology, and immunology have enabled researchers to grow and modify T lymphocytes ex\u2010vivo. Chimeric antigen receptor (CAR) T\u2010cell therapy has been shown to specifically target cells of lymphoid lineage and induce remission in acute lymphoblastic leukemia (ALL) patients. While the success of CAR T\u2010cells against ALL is considered a defining moment in modern oncology, similar efficacy against myeloid leukemia cells remains elusive. Over the past 10 years, numerous CAR T\u2010cells have been developed that can target novel myeloid antigens, and many clinical trials are finally starting to yield encouraging results. In this review, we present the recent advances in this field and discuss strategies for future development of myeloid targeting CAR T\u2010cell therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The field of CAR T\u2010cell therapy has rapidly evolved over the past few years. It represents a radically new approach towards cancers, and with continued refinement it may become a viable therapeutic option for patients of acute and chronic myeloid leukemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1222","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T21:38:14Z","timestamp":1578519494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Finding new lanes: Chimeric antigen receptor (CAR) T\u2010cells for myeloid leukemia"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-737X","authenticated-orcid":false,"given":"Suraj","family":"Pratap","sequence":"first","affiliation":[{"name":"University of Oklahoma Health Sciences Center Department of Pediatric Hematology\u2010Oncology  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhuang J.","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center Department of Pathology  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"volume-title":"SEER Cancer Statistics Review","year":"2017","author":"Noone AM","key":"e_1_2_4_2_1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61403-3"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002842"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10024"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46110"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3838"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25960"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1046430"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2013.32"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0075-3"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006597"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.262"},{"key":"e_1_2_4_14_1","unstructured":"LiuX RanganathanR JiangS FangC SunJ KimS NewickK LoA JuneCH ZhaoY MoonEK.Therapeutics targets and chemical biology. A chimeric switch\u2010receptor targeting PD1 augments the efficacy of second\u2010generation CAR T cells in advanced solid tumors.2016;"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4047"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0019"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200796"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0130"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2008.04.010"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2018.05.001"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.4052.4052"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.TPS3093"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186742"},{"issue":"3","key":"e_1_2_4_24_1","first-page":"1553","article-title":"Expression of Lewisa, Lewisb, X, and Y blood group antigens in human colonic tumors and normal tissue and in human tumor\u2010derived cell lines","volume":"46","author":"Sakamoto J","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1711.2005.01374.x"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.21"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.154"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1155"},{"issue":"1","key":"e_1_2_4_29_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5858\/2003-127-42-FCAOA","article-title":"Flow cytometric analysis of acute leukemias diagnostic utility and critical analysis of data","volume":"127","author":"Kaleem Z","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.026310"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/683065"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.164"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.112748"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.52"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.013"},{"issue":"12","key":"e_1_2_4_36_1","first-page":"1261","article-title":"Interleukin\u20103 receptor alpha chain (CD123) is widely expressed in hematologic malignancies","volume":"86","author":"Mu\u00f1oz L","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500272507"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-4441.2003.00184.x"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401903"},{"issue":"1","key":"e_1_2_4_40_1","first-page":"1917","article-title":"Anti\u2010CD123 CAR T\u2010cell therapy for the treatment of myelodysplastic syndrome","volume":"130","author":"Zhang W","year":"2017","journal-title":"Blood"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0422"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.3778.3778"},{"key":"e_1_2_4_43_1","doi-asserted-by":"crossref","unstructured":"GillS TasianSK RuellaM ShestovaO LiY CarrollM Danet\u2010DesnoyersG SchollerJ GruppSA JuneCH.Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor\u2010modified T cells.Blood.2014;123(15):2343\u201054","DOI":"10.1182\/blood-2013-09-529537"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-474056"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.62"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-55651-0_25"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.014"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431062"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.9.2399.2399"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.10.001"},{"issue":"4","key":"e_1_2_4_51_1","first-page":"588","article-title":"Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells","volume":"10","author":"Drexler HG","year":"1996","journal-title":"Leukemia"},{"issue":"5","key":"e_1_2_4_52_1","first-page":"1532","article-title":"The roles of FLT3 in hematopoiesis and leukemia","volume":"100","author":"Gary Gilliland D","year":"2002","journal-title":"Blood, The Journal of the American Society of Hematology"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.1072.1072"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.147"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0009-0"},{"volume-title":"Generation and characterization of FLT3 ligand\u2010containing chimeric antigen receptor (CAR) T\u2010lymphocytes. In Pediatric Blood & Cancer","year":"2018","author":"Pratap S","key":"e_1_2_4_56_1"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0603-7"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.766.766"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112259"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0553-5"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.05.024"},{"issue":"1","key":"e_1_2_4_62_1","first-page":"70","article-title":"Flow cytometric characterization of acute myeloid leukemia. Part II. Phenotypic heterogeneity at diagnosis","volume":"6","author":"Terstappen LW","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000058769"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.137620"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3181adaff1"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.73"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.361"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990115)85:2<348::AID-CNCR12>3.0.CO;2-4"},{"key":"e_1_2_4_69_1","doi-asserted-by":"crossref","unstructured":"PanXQ ZhengX ShiG WangH RatnamM LeeRJ.Strategy for the treatment of acute myelogenous leukemia based on folate receptor \u03b2\u2010targeted liposomal doxorubicin combined with receptor induction using all\u2010trans retinoic acid.2002;","DOI":"10.1182\/blood.V100.2.594"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.10.3529"},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-612721"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.045"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704271104"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000349"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.04.007"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679985"},{"key":"e_1_2_4_77_1","unstructured":"WardaW LarosaF Da RochaMN TradR DeconinckE FajlounZ FaureC CaillotD MoldovanM Valmary\u2010DeganoS BiichleS.CML hematopoietic stem cells expressing IL\u20101RAP can be targeted by chimeric antigen receptor (CAR)\u2010engineered T cells. Cancer Res.2018Dec 4;canres.1078.2018."},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166891"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T19:22:04Z","timestamp":1694028124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/cnr2.1222"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1222","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2020,1,8]]},"assertion":[{"value":"2019-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1222"}}