{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:27Z","timestamp":1753868667289,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coeliac plexus block (CPB) is an interventional pain management option for patients with pancreatic or other upper abdominal malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the safety, utilization, and outcomes of CPBs in the local context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We conducted a retrospective case series of all patients with cancer who underwent CPB at 4 Sydney teaching hospitals from March 2010 to February 2016. We recorded baseline demographic data, details of the injectate, procedural approach and survival, as well as pain scores and analgesic use at 4 time points of interest. Thirty\u2010nine procedures were performed during the study period. Twenty\u2010four were performed endoscopically, 14 were performed via a bilateral percutaneous posterior approach by Pain Specialists or Radiologists and 1 was performed intraoperatively by a Surgeon. Patients had experienced pain for a mean of 17\u2009weeks prior to CPB. Prior to CPB, the mean pain score was 8.8 out of 10. The mean pain score was reduced at 48\u2009hours, 2\u2009weeks, and 4\u2009weeks following CPB (<jats:italic>P<\/jats:italic> &lt;\u2009.01). The mean oral morphine equivalent daily dose prior to CPB was 362\u2009mg which was reduced at 48\u2009hours and 2\u2009weeks but increased at the 4\u2009weeks following CPB. One patient developed a bacteremia but otherwise no complications were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CPB is performed by a number of approaches and is well tolerated. The approach selected appears to depend on patient anatomy, preference, and availability of local expertise. Local clinicians could consider CPB earlier in the management of malignant epigastric pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1265","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T17:39:10Z","timestamp":1595266750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A retrospective case series of patients who have undergone coeliac plexus blocks for the purpose of alleviating pain due to intra\u2010abdominal malignancy"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-3454","authenticated-orcid":false,"given":"Alix","family":"Dumitrescu","sequence":"first","affiliation":[{"name":"Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital  Camperdown New South Wales Australia"},{"name":"Central Clinical School University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-9572","authenticated-orcid":false,"given":"Richard","family":"Chye","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital  Darlinghurst New South Wales Australia"},{"name":"University of Notre Dame Australia  Darlinghurst New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200506000-00027"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00189-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13609"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.161.5.8273610"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199204000-00008"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199305010-00004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200103000-00012"},{"key":"e_1_2_12_10_1","unstructured":".ArcidiaconoPG CaloriG CarraraS McNicolED TestoniPA. 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