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To the best of our knowledge there are only a few cases of PPE reported with methotrexate infusion to date.<\/jats:p><\/jats:sec>Case and Conclusion<\/jats:title>We report a case of Burkitt Lymphoma, who developed severe PPE with methotrexate infusion and responded very well with conservative management and dose reduction in subsequent cycles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1270","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T13:05:15Z","timestamp":1596805515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Palmar\u2010plantar erythrodysesthesia associated with high\u2010dose methotrexate: Case report"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-8031","authenticated-orcid":false,"given":"Priyanka","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshul","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujeet","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arijit","family":"Bishnu","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soniya","family":"Nityanand","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30762"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2006.10.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182580ba0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2008.02.021"},{"volume-title":"Palmar\u2010Plantar Erythrodysesthesia, Palmoplantar Erythrodysesthesia, Hand\u2010Foot Syndrome","author":"Chidharla A","key":"e_1_2_9_7_1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(08)74677-5"},{"issue":"9","key":"e_1_2_9_9_1","first-page":"1161","article-title":"Coming to grips with hand\u2010foot syndrome. 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