{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:48:25Z","timestamp":1790819305074,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T00:00:00Z","timestamp":1596931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreatic cancer is associated with a dismal prognosis, with ductal adenocarcinoma being the most common form of primary neoplasm diagnosed. Clear cell carcinoma is usually associated with kidney, ovarian or bladder malignancy but rarely associated with pancreatic malignancy. According to the WHO classification, primary clear cell adenocarcinoma of the pancreas is a rare \u201cmiscellaneous\u201d carcinoma, and to date few cases have been reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 63\u2010year old female who presented to a metropolitan hospital in Australia with abdominal pain suggestive of pancreatitis. Abdominal computed tomography subsequently demonstrated a necrotic mass in the neck of the pancreas with hepatic metastasis. Subsequent histopathological and immunohistochemical analysis was consistent with pancreatic clear cell adenocarcinoma. The patient was discharged to home to commence on dose reduced nab\u2010paclitaxel and gemcitabine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case reports a rare variant of pancreatic malignancy and contributes further evidence to the body of literature highlighting clear cell adenocarcinoma as a histological subtype of pancreatic neoplasm, albeit rare in nature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1273","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T01:30:40Z","timestamp":1597023040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clear cell adenocarcinoma presenting as acute pancreatitis: A rare form of primary pancreatic malignancy"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-2248","authenticated-orcid":false,"given":"Robert S.","family":"O'Neill","sequence":"first","affiliation":[{"name":"The Department of Medical Oncology The Sutherland Hospital  Caringbah New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn L.","family":"Lam","sequence":"additional","affiliation":[{"name":"The Department of Medical Oncology The Sutherland Hospital  Caringbah New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parthsinh","family":"Solanki","sequence":"additional","affiliation":[{"name":"The Department of Medical Oncology The Sutherland Hospital  Caringbah New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Levingston","sequence":"additional","affiliation":[{"name":"Department of Histopathology Douglass Hanly Moir Pathology  Sydney Australia"},{"name":"School of Medicine Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Thomas","sequence":"additional","affiliation":[{"name":"The Department of Medical Oncology The Sutherland Hospital  Caringbah New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,9]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Tumors of the Pancreas. Atlas of Tumor Pathology, 4th Series, Fascicle","author":"Hruban RH","year":"2007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S183054"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.04.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.14.5619"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-289"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318299f12e"},{"key":"e_1_2_9_8_1","first-page":"8765264","article-title":"Asymptomatic pancreatic metastasis from renal cell carcinoma diagnosed 21years after nephrectomy","volume":"2017","author":"Zianne M","year":"2017","journal-title":"Case Rep Gastrointest Med"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.124"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.15.6569"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.95"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcnr2.1273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:52:54Z","timestamp":1693810374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,9]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/cnr2.1273"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1273","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,9]]},"assertion":[{"value":"2020-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1273"}}