{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:06:22Z","timestamp":1778555182824,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment of non\u2010melanoma skin cancer and deadliest malignant melanoma skin cancer are the fifth and ninth most expensive treatments in Medicare, respectively. Moreover, the recurrence of cancer after currently available therapies, that is, surgery or radiotherapy, reduces the patient's life expectancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In view of this, we fabricated magnetic nanofibrous mat\u2010based bandage to treat skin cancer non\u2010invasively using an external alternating current (AC) magnetic field induced hyperthermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles incorporated polycaprolactone (PCL) fibers based bandages were fabricated using the electrospinning technique. The efficacy of the bandage was investigated in vitro using parental\/doxorubicin hydrochloride (Dox)\u2010resistant HeLa cells and in vivo using BALB\/c mouse model in the presence of an external AC magnetic field (AMF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PCL\u2010Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> fibrous mat\u2010based bandages dissipate heat energy locally on the application of an external AMF and increase the surrounding temperature in a controlled way up to 45\u00b0C in a few mins. The in vitro study confirms the elevated temperature could kill parental and Dox\u2010resistant HeLa cells significantly. As the activity of Dox enhanced at a higher temperatures, more than 85% of parental HeLa cells were dead when cells incubated with Dox contained fibrous mat in the presence of AMF for 10 minutes. Further, we confirm the full recovery of chemically induced skin tumors on BALB\/c mice within a month after five hyperthermic doses for 15\u2009minutes. Also, there was no sign of inflammation and recurrence of cancer post\u2010therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study confirms the PCL\u2010Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanofibrous based bandages are unique and compelling to treat skin cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1281","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T13:14:25Z","timestamp":1599138865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Magnetic nanofibers based bandage for skin cancer treatment: a non\u2010invasive hyperthermia therapy"],"prefix":"10.1002","volume":"3","author":[{"given":"Kaushik","family":"Suneet","sequence":"first","affiliation":[{"name":"Centre for Biosystems Science and Engineering Indian Institute of Science  Bangalore Karnataka 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