{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:30Z","timestamp":1753868670753,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. <jats:italic>BCR\u2010ABL<\/jats:italic> rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, <jats:italic>BCR \u2010ABL<\/jats:italic> \u2010 is the commonest recurrent abnormality whereas, <jats:italic>IgH<\/jats:italic> rearrangements are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Aim of this study was to identify common recurrent genetic abnormalities in adult B ALL and study their association with hematological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bone marrow and peripheral blood from patients with B acute lymphoblastic leukemia were analyzed for complete blood counts, bone marrow morphology and cytogenetic abnormalities. The study group was divided into smaller groups based on cytogenetic abnormalities. Hematological parameters and presence of recurrent genetic abnormalities was compared across age groups and gender by non parametric tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>BCR\u2010ABL<\/jats:italic> positive group had a higher leukocyte count than <jats:italic>BCR\u2010ABL<\/jats:italic> negative group. Among groups 1 to 5, group 1 with gains of chromosomes was associated with leucopenia and higher age at presentation. <jats:italic>BCR\u2010ABL<\/jats:italic> is commonest recurrent abnormality followed by <jats:italic>IgH<\/jats:italic> rearrangements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with gains of chromosomes alone have low total leukocyte counts at presentation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1290","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T14:13:11Z","timestamp":1601043191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent genetic abnormalities detected by <scp>FISH<\/scp> in adult B <scp>ALL<\/scp> and association with hematological parameters"],"prefix":"10.1002","volume":"3","author":[{"given":"Anil","family":"Tarigopula","sequence":"first","affiliation":[{"name":"Department of Centralised Molecular Diagnostics, Apollo Hospitals  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-1486","authenticated-orcid":false,"given":"Vani","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"Department of Hematology Apollo Hospitals  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govindasami","family":"Perumal","sequence":"additional","affiliation":[{"name":"Department of Centralised Molecular Diagnostics, Apollo Hospitals  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1038\/bcj.2017.53"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.3324\/haematol.2012.080432"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1002\/ajh.1083"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1182\/blood-2008-01-130237"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1038\/sj.leu.2400959"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/S0305-7372(03)00140-3"},{"key":"e_1_2_8_8_1","first-page":"3983","article-title":"Prospective karyotype analysis in adult acute lymphoblastic leukemia: the cancer and leukemia group B experience","volume":"93","author":"Wetzler 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