{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:30Z","timestamp":1753868670162,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Medullary thyroid carcinoma very rarely metastasizes to the breast. Hematogenous spread to the liver, lungs, or mediastinum is more common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We describe the morphologic and immunohistochemical features of a 63\u2010year\u2010old woman who presented with a BIRADS\u20105 category nodule in the right breast and enlarged axillary lymph nodes. Core biopsy showed suggested breast cancer with neuroendocrine or apocrine differentiation. The immunohistochemical profile showed (RE\u2212\/RP\u2212\/HER\u20102\u2212) and Ki67 10%. Chromogranin and synaptophysin were positive; AR and GCDFP\u201015 were negative. On reviewing the patient's clinical history, it was discovered that she had been treated for medullary thyroid carcinoma 15\u2009years earlier. Additional stains showed positivity for TTF\u20101, CEA, and calcitonin. These findings were consistent with a diagnosis of breast metastasis from medullary thyroid carcinoma. We discuss briefly the morphologic features and the possible key features in order to make an accurate diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights the importance of investigating a history of cancer in patients with discordant or unusual histologic or immunohistochemical findings, as this can help avoid misdiagnosis and inappropriate treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1292","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T12:34:01Z","timestamp":1602074041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Breast metastasis from medullary thyroid carcinoma mimicking ductal carcinoma with neuroendocrine differentiation"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-513X","authenticated-orcid":false,"given":"Juan B.","family":"Laforga","sequence":"first","affiliation":[{"name":"Department of Pathology Hospital de Denia  Denia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital de Denia  Denia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Ignacio","family":"Aranda","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital General Universitario de Alicante  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"volume-title":"WHO Classification of Tumours of Endocrine Organs","year":"2017","author":"Lloyd RV","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<564::AID-CNCR20>3.0.CO;2-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.129.4.673"},{"key":"e_1_2_8_5_1","first-page":"251","article-title":"Metastases to the breast from extramammary carcinomas","volume":"89","author":"Nielsen M","year":"1981","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011101)92:9<2259::AID-CNCR1571>3.0.CO;2-O"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.191"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.1.7785635"},{"key":"e_1_2_8_9_1","first-page":"561","article-title":"Metastasis to the breast","volume":"20","author":"Paulus DD","year":"1982","journal-title":"Radio Clin North Am"},{"key":"e_1_2_8_10_1","first-page":"441","article-title":"Medullary thyroid carcinoma metastatic to breast masquerading as infiltrating lobular carcinoma","volume":"24","author":"Ali SZ","year":"1994","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2006.08.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013193"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.228217"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24342"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:44:55Z","timestamp":1693824295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,7]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/cnr2.1292"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1292","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2020,10,7]]},"assertion":[{"value":"2020-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1292"}}