{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:31Z","timestamp":1753868671532,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Olfactory neuroblastoma (ONB) is a sinonasal malignancy seldom seen in clinical practice. It is also known by various other names like esthesioneuroblastoma, esthesioneuroepithelioma, esthesioneurocytoma, and esthesioneuroma. Surgery and radiation therapy are considered as standard treatment modalities for ONB; however, the role of chemotherapy is not well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aim to define the role of chemotherapy in the neoadjuvant setting in a case of ONB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We report a young female patient presenting with a naso\u2010facial swelling causing facial disfigurement, proptosis, decreased visual acuity, and poor performance status. She was diagnosed with advanced\u2010stage ONB. Prompt administration of chemotherapy led to the improvement in the symptoms and rapid regression of the tumor mass. Later on, the tumor mass was excised completely without any neurological deficit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report justifies the role of neoadjuvant chemotherapy in the management of ONB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1303","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T08:03:32Z","timestamp":1602144212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Facial disfigurement due to olfactory neuroblastoma: beauty regained with chemotherapy"],"prefix":"10.1002","volume":"4","author":[{"given":"Parmod","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Hematology All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-7694","authenticated-orcid":false,"given":"Deepak","family":"Sundriyal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rekha","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhinyaram","family":"Jat","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-8999","authenticated-orcid":false,"given":"Amit","family":"Sehrawat","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0125-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197603)37:3<1571::AID-CNCR2820370347>3.0.CO;2-L"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199305000-00002"},{"key":"e_1_2_9_5_1","first-page":"240","volume-title":"Atlas of tumor pathology. 2nd series. Fascicle","author":"Hyams VJ","year":"1988"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0547-3"},{"issue":"6","key":"e_1_2_9_7_1","first-page":"e4897","article-title":"Esthesioneuroblastoma: summary of single\u2010center experiences with focus on adjuvant therapy and overall survival","volume":"11","author":"Alotaibi HA","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.03.014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-014-0423-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199004000-00010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25209"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2017.07.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24822"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104618"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000649"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T04:36:58Z","timestamp":1693715818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/cnr2.1303"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1303","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"assertion":[{"value":"2020-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1303"}}