{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:59:15Z","timestamp":1756076355469,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant mediastinal germ cell tumor (MGCT) is rare and has poor outcomes even after multimodality treatment. Data from resource\u2010poor countries are scarce in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the clinicopathologic features and treatment outcome of primary malignant MGCT at our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Single institutional data review of patients aged \u226518\u2009years, treated with a diagnosis of malignant MGCT between Nov'2013 and Nov'2019. Risk stratification was done as per International Germ Cell Cancer Collaborative Group (IGCCCG) classification. Patients were treated with platinum based chemotherapy and surgical resection for the residual disease was performed in non\u2010seminomatous histology.28 patients had MGCT with a median age of 25\u2009years (range:18\u201036) and all were male. Seven patients had superior vena cava obstruction (SVCO) at diagnosis and pre\u2010treatment histological diagnosis was available in 23 (82%) patients. Seven (25%) patients had seminoma histology, all were of good risk as per IGCCCG risk criteria, whereas others had non\u2010seminoma histology with poor\u2010risk group. Seven patients with seminoma histology achieved a complete response after initial treatment. Six patients with non\u2010seminoma histology underwent complete resection of residual disease post\u2010chemotherapy and five revealed residual viable tumors. After a median follow\u2010up of 10.8 months (range:2.9\u201075), 3\u2010year progression\u2010free survival (PFS) and overall survival (OS) estimate was 61.2% and 94.7% in the whole cohort, respectively and 3\u2010year PFS and OS estimate was 100% in patients with seminoma histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the largest data set of MGCT patients' outcomes reported from India with multi\u2010modality treatment. All patients were male and one\u2010fourth had SVCO at presentation. Seminoma histology patients had a 100% outcome after initial platinum based chemotherapy. But, those with non\u2010seminoma histology had a poor outcome even with chemotherapy and surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1306","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T08:53:11Z","timestamp":1602147191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multimodality treatment outcome in patients with primary malignant mediastinal germ cell tumor in adults"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-5500","authenticated-orcid":false,"given":"Bivas","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Dabkara","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tata Medical Center  Kolkata 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