{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:19:37Z","timestamp":1762341577208,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Only few studies in literature have analyzed the clinical effects of peritoneal lavage status in biliary tract cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to assess the effect of cytology\u2010positive peritoneal lavage on survival for patients with biliary tract cancer who underwent curative resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The KHBO1701 study was a multi\u2010institutional retrospective study that assessed the clinical effects of peritoneal lavage cytology in biliary tract cancers. Using clinicopathological data from 11 Japanese institutions, we compared long\u2010term outcomes between patients with cytology\u2010positive and cytology\u2010negative peritoneal lavage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 169 patients who underwent curative resection, 164 were cytology\u2010negative, and five were cytology\u2010positive. The incidence of portal invasion and preoperative carbohydrate antigen 19\u20109 levels were higher in the cytology\u2010positive group than in the cytology\u2010negative group. The incidence of peritoneal metastatic recurrence was also higher, and overall survival tended to be worse in the cytology\u2010positive group. In contrast, recurrence\u2010free survival was similar between the cytology\u2010negative and cytology\u2010positive groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The positive status of peritoneal lavage cytology could moderately affect the survival of patients with biliary tract cancers. Given that surgical resection is the only curative treatment option, it may be acceptable to resect biliary tract cancers without other non\u2010curative factors, regardless of peritoneal lavage cytology status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1323","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T02:31:54Z","timestamp":1607308314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of peritoneal lavage cytology in biliary tract cancer (<scp>KHBO1701<\/scp>): Kansai <scp>Hepato\u2010Biliary<\/scp> Oncology Group"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6749-0222","authenticated-orcid":false,"given":"Satoshi","family":"Matsukuma","sequence":"first","affiliation":[{"name":"Department of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine  Yamaguchi 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