{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:19:14Z","timestamp":1790014754198,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prevalent symptoms that affect children and adolescents throughout the process of cancer diagnosis and treatment include nausea and vomiting, fatigue, pain, mucositis, and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the effect of a home\u2010based multimodal symptom\u2010management program for alleviation of nausea and vomiting, fatigue, pain, mucositis, and anxiety in children and adolescents undergoing chemotherapy for hematological malignancies or solid tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an exploratory pilot randomized study with qualitative interview, patients between 10 and 18\u2009years of age were randomly assigned to either the symptom\u2010management program plus usual care (intervention group) or usual care (control group). The program consisted of multiple nonpharmacological interventional components. The targeted symptoms were measured at baseline (after diagnosis), at the first 2\u2009weeks of each cycle of chemotherapy, and at 6\u00a0months after baseline, using the Memorial Symptom Assessment Scale 10\u201018 and the State Anxiety Scale for Children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty children (31 boys; mean age, 13.7\u2009years) were randomized either to the intervention group or the control group (25 each) and underwent baseline assessment. A comparison between the groups showed that the intervention group had a significant less fatigue over time (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). However, no differences were found with respect to nausea and vomiting, pain, mucositis, and anxiety between groups. Both children and parents reported a positive experience with the symptom\u2010management program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The home\u2010based symptom\u2010management program may have helped to reduce fatigue in children and adolescents undergoing chemotherapy. In addition, qualitative data support the importance of improving children and parents' knowledge, coping skills, and psychological preparation for symptoms associated with chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1336","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T02:50:05Z","timestamp":1613616605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A pilot study of the effect of a home\u2010based multimodal symptom\u2010management program in children and adolescents undergoing chemotherapy"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-4771","authenticated-orcid":false,"given":"Karis Kin\u2010Fong","family":"Cheng","sequence":"first","affiliation":[{"name":"Alice Lee Centre for Nursing Studies Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Mei Lian","family":"Tan","sequence":"additional","affiliation":[{"name":"Paediatric Oncology, Department of Paediatrics Khoo Teck Puat National University Children's Medical Institute  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0115"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e31821aedba"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"465","article-title":"Symptom clusters and their effect on the functional status of patients with cancer","volume":"28","author":"Dodd MJ","year":"2001","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2010.05.011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454210377619"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000264"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29876"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e3182207a2a"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000469"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e32835ad551"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3253-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2018.11.007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27932"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1188\/06.ONF.641-646"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1363c"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200312000-00007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25029"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.12.019"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgm005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156911"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20111"},{"issue":"1","key":"e_1_2_10_23_1","first-page":"CD006953","article-title":"Psychosocial interventions for reducing fatigue during cancer treatment in adults","volume":"2009","author":"Goedendorp MM","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04891-1"},{"key":"e_1_2_10_25_1","volume-title":"Social Foundations of Thought and Action: A Social Cognitive Theory","author":"Bandura A","year":"1986"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(00)00127-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2005.12.004"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199915020-00003"},{"key":"e_1_2_10_29_1","first-page":"e2784","article-title":"Fatigue in children and adolescents with cancer from the perspective of health professionals","volume":"24","author":"Miyauti\u2010Silva MC","year":"2016","journal-title":"Rev Latino\u2010Am Enfermagem"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2016-001132"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/wvn.12007"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12381"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1367493517752498"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2014.0023"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-014-9618-7"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1336","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:13:27Z","timestamp":1693300407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/cnr2.1336"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1336","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"assertion":[{"value":"2020-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1336"}}