{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:33Z","timestamp":1753868673856,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcomatoid renal cell carcinoma (SRCC) is associated with poor prognosis. Although there is no standard treatment for SRCC, recent studies have reported the effectiveness of immune checkpoint inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>An 82\u2010year\u2010old Japanese man presented to our hospital with an incidental right renal tumor. Abdominal computed tomography (CT) showed an exophytic tumor in the right kidney with suspected right iliopsoas muscle invasion. Laparoscopic right radical nephrectomy was performed. Histopathological diagnosis revealed a clear cell RCC with a spindle cell carcinoma component. CT performed 3\u00a0months after surgery revealed multiple bilateral lung metastases and local recurrence. Although the patient received tyrosine\u2010kinase inhibitors for treating multiple metastases, the lung metastases continued to gradually increase, and peritonitis carcinomatosis was observed. Thus, the patient was intravenously administered nivolumab once every 2\u2009weeks. After nivolumab administration, lung metastases, local recurrence, and peritonitis carcinomatosis gradually reduced. After 20\u2009months of nivolumab treatment, the patient achieved a complete response of multiple metastases on CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nivolumab may be used as a treatment option for sarcomatoid renal cell carcinoma with multiple metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1356","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T16:32:50Z","timestamp":1614789170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of multiple metastatic sarcomatoid renal cell carcinoma with complete response to nivolumab"],"prefix":"10.1002","volume":"4","author":[{"given":"Masayuki","family":"Tomioka","sequence":"first","affiliation":[{"name":"Department of Urology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Japanese Red Cross Takayama Hospital  Takayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-8432","authenticated-orcid":false,"given":"Natsuko","family":"Suzui","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu University Graduate School of Medicine  Gifu 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+ cabozantinib vs sunitinib in first\u2010line treatment for advanced renal cell carcinoma: first results from the randomized phase III CheckMate 9ER trial","volume":"31","author":"Choueiri TK","year":"2020","journal-title":"Ann Oncol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.0000"},{"issue":"17","key":"e_1_2_9_15_1","first-page":"30238","article-title":"Phase 2 trial of capecitabine, gemcitabine, and bevacizumab in sarcomatoid renal\u2010cell carcinoma","volume":"1558","author":"Maiti A","year":"2017","journal-title":"Clin Genitourin Cancer"},{"issue":"8","key":"e_1_2_9_16_1","first-page":"1606639","article-title":"Metastatic sarcomatoid renal cell carcinoma treated with immune checkpoint inhibitors","volume":"8","author":"Hanif A","year":"2019","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30937"}],"container-title":["Cancer 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