{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:01:22Z","timestamp":1782226882149,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical outcomes of novel coronavirus 2019 disease (COVID\u201019) in onco\u2010hematological patients are unknown. When compared to non\u2010immunocompromised patients, onco\u2010hematological patients seem to have higher mortality rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We describe the characteristics and outcomes of a consecutive cohort of 24 onco\u2010hematological patients with COVID\u201019 during the first month of the pandemic. We also describe variations in healthcare resource utilization within our hematology department.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Data from patients between the first month of the pandemic were retrospectively collected. Clinical and logistic data were also collected and compared with the average values from the prior 3\u2009months of activity. Prevalence of COVID\u201019 in our hematological population was 0.4%. Baseline characteristics were as follows: male sex: 83%, lymphoid diseases: 46%, median age: 69 (22\u201082) years. Median follow\u2010up in survivors was 14 (9\u201028) days and inpatient mortality rate was 46%. Average time to moderate\/severe respiratory insufficiency and death were 3 (1\u201010) and 10 (3\u201018) days, respectively. Only 1 out of every 12 patients who developed moderate to severe respiratory insufficiency recovered. Upon univariate analysis, the following factors were associated with higher mortality: age\u2009\u2265\u200970\u2009years (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) and D\u2010dimer \u2265900\u2009mcg\/L (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). With respect to indirect effects during the COVID\u201019 pandemic, and when compared with the prior 3\u2009months of activity, inpatient mortality (excluding patients with COVID\u201019 included in the study) increased by 56%. This was associated with a more frequent use of vasoactive drugs (+300%) and advanced respiratory support (+133%) in the hematology ward. In the outpatient setting, there was a reduction in initial visits (\u221255%) and chemotherapy sessions (\u221219%). A significant increase in phone visits was reported (+581%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 pandemic is associated with elevated mortality in hematological patients. Negative indirect effects are also evident within this setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1358","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T13:41:17Z","timestamp":1614778877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The direct and indirect effects of <scp>COVID\u201019<\/scp> pandemic in a real\u2010life hematological setting"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-325X","authenticated-orcid":false,"given":"Maria","family":"Condom","sequence":"first","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mussetti","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6413","authenticated-orcid":false,"given":"Clara","family":"Maluquer","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Parody","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-1508","authenticated-orcid":false,"given":"Eva","family":"Gonz\u00e1lez\u2010Barca","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"},{"name":"Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Arnan","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaia","family":"Albasanz\u2010Puig","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD16\/0016\/0001) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Infectious Diseases Department Bellvitge University Hospital, IDIBELL, University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Pomares","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Queralt","family":"Salas","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2014Hospital Duran i Reynals  Barcelona 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Accessed April 12 2020."}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1358","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:56:00Z","timestamp":1693356960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/cnr2.1358"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1358","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"2020-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1358"}}