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Types of allografts were kidney (n\u00a0=\u00a012), liver (n\u00a0=\u00a07), heart (n\u00a0=\u00a05), hematopoietic stem cells (n\u00a0=\u00a04), lungs (n\u00a0=\u00a02), multi\u2010visceral (n\u00a0=\u00a02), small intestine (n\u00a0=\u00a01), and vessels (n\u00a0=\u00a01). Eighteen\/34 were classified as monomorphic PTLD, with DLBCL accounting for 15 cases. Polymorphic disease occurred in nine, and non\u2010destructive lesions in six cases. One patient had a non\u2010classifiable PTLD. Thirteen\/34 patients are surviving event\u2010free in first remission (non\u2010destructive, n\u00a0=\u00a04\/6; polymorphic, n\u00a0=\u00a04\/9; monomorphic, n\u00a0=\u00a06\/18). Fourteen\/34 patients lacked complete response to first\u2010line therapy, of whom seven died. Four\/34 patients relapsed, of whom two died. In 3\/34 patients, death occurred as a first event. The 5\u2010year overall and event\u2010free survival rates were 64%\u2009\u00b1\u20099% and 35%\u2009\u00b1\u20099% for the whole cohort. Among all parameters analyzed, only malignant disease as the indication for transplantation had a significantly poor influence on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows PTLD still to be a major cause of mortality following SOT or HSCT in children. A continued understanding of the molecular biology of the disease shall allow to decrease treatment intensity for lower risk patients and to identify patients who may benefit from newer therapy approaches to improve outcome and decrease morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1375","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T12:40:15Z","timestamp":1616503215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characteristics, management, and outcome of pediatric patients with post\u2010transplant lymphoproliferative disease\u2014A 20\u2009years' experience from Austria"],"prefix":"10.1002","volume":"4","author":[{"given":"Anna","family":"F\u00fcreder","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology St. Anna Children's Hospital  Vienna Austria"},{"name":"Department of Pediatrics and Adolescent Medicine Medical 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