{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:56:45Z","timestamp":1765486605179,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Colorectal cancer is one of the most common cancers and the leading cause of cancer\u2010related death worldwide. Early diagnostic methods help in therapeutic success and higher survival rate. Golgi protein 73 (gp73) could help in diagnosis of colorectal cancer at an earlier stage.<\/jats:p><\/jats:sec>Aim<\/jats:title>A case\u2010control study aimed to assess serum level of golgi protein 73 (gp73) as a liquid biopsy marker in Egyptian colorectal cancer patients.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>In the current study, ninty (90) patients were included and classified into three groups; thirty (30) patients with Colorectal cancer (CRC) as study group; 30 patients (20 patients with irritable bowel disease and 10 patients with rectal polyps) as pathological control and 30 healthy adult individuals as normal control. The diagnosis was based on the history, clinical, laboratory, endoscopic, and histological data. Golgiprotein 73 (GP73) was measured by ELISA immunoassay Kit. Serum GP73 level was higher in CRC patients than pathological control group and normal control group with high sensitivity and specificity p<\/jats:italic>\u00a0<\u2009.005.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>GP73 alone or combined with Carcinoembryonic antigen (CEA) may be good diagnositic marker in CRC. However large studies are warranted on different stages of the disease to assess its diagnostic and prognositic value.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1379","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T11:09:25Z","timestamp":1621508965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical significance of golgi protein\u201073 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study"],"prefix":"10.1002","volume":"4","author":[{"given":"Shaymaa Abdelraheem","family":"Abdelhady","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology Suez Canal University Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Attya","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Suez Canal University Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Suez Canal University Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5262-0699","authenticated-orcid":false,"given":"Fadia M.","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Suez Canal University Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120425","article-title":"Blood\u2010based protein biomarker panel for the detection of colorectal cancer","volume":"10","author":"Kim YC","year":"2015","journal-title":"PLOS One"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.104"},{"key":"e_1_2_10_4_1","article-title":"Biomarkers in colorectal cancer: the role of translational proteomics research","author":"Martins BA","year":"2019","journal-title":"Front Oncol"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"18","article-title":"Colorectal cancer screening: recommendations for physicians and patients from the U.S. multi\u2010society task force on colorectal cancer. The American College of Gastroenterology","volume":"86","author":"Rex DK","year":"2017","journal-title":"The American Journal of Gastroenterology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2018.04.23"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"551","article-title":"Overexpression of golgi membrane protein 1 promotes non\u2010small\u2010cell carcinoma aggressiveness by regulating the matrix metallopeptidase 13","volume":"8","author":"Arunaand Li ML","year":"2018","journal-title":"Am J Cancer Res"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02535-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.29.15_suppl.e14089"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2018.08.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v6.i4.83"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-018-1820-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.59.280"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2013.67.397-401"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"HauptmanN Glava\u010dD.Colorectal cancer blood\u2010based biomarkers.Gastroenterol. Res. Pract.2017:11.","DOI":"10.1155\/2017\/2195361"},{"issue":"6","key":"e_1_2_10_16_1","first-page":"2455","article-title":"Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients","volume":"39","author":"Konstantinos TN","year":"2018","journal-title":"Oncol Rep"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.1.11"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408928102"},{"issue":"5","key":"e_1_2_10_19_1","first-page":"81","article-title":"Study of serum Dickkopf\u20101, and Golgi membrane protein in Egyptian patients with colorectal cancer","volume":"5","author":"El\u2010Zefzafy WM","year":"2015","journal-title":"Clin Med Diagn"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:15:00Z","timestamp":1693199700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,20]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/cnr2.1379"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1379","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2021,5,20]]},"assertion":[{"value":"2020-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1379"}}