{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:14:13Z","timestamp":1771892053272,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The understanding of the impact of COVID\u201019 in patients with cancer is evolving, with need for rapid analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aims to compare the clinical and demographic characteristics of patients with cancer (with and without COVID\u201019) and characterize the clinical outcomes of patients with COVID\u201019 and cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Real\u2010world data (RWD) from two health systems were used to identify 146\u2009702 adults diagnosed with cancer between 2015 and 2020; 1267 COVID\u201019 cases were identified between February 1 and July 30, 2020. Demographic, clinical, and socioeconomic characteristics were extracted. Incidence of all\u2010cause mortality, hospitalizations, and invasive respiratory support was assessed between February 1 and August 14, 2020. Among patients with cancer, patients with COVID\u201019 were more likely to be Non\u2010Hispanic black (NHB), have active cancer, have comorbidities, and\/or live in zip codes with median household income &lt;$30\u2009000. Patients with COVID\u201019 living in lower\u2010income areas and NHB patients were at greatest risk for hospitalization from pneumonia, fluid and electrolyte disorders, cough, respiratory failure, and acute renal failure and were more likely to receive hydroxychloroquine. All\u2010cause mortality, hospital admission, and invasive respiratory support were more frequent among patients with cancer and COVID\u201019. Male sex, increasing age, living in zip codes with median household income &lt;$30\u2009000, history of pulmonary circulation disorders, and recent treatment with immune checkpoint inhibitors or chemotherapy were associated with greater odds of all\u2010cause mortality in multivariable logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RWD can be rapidly leveraged to understand urgent healthcare challenges. Patients with cancer are more vulnerable to COVID\u201019 effects, especially in the setting of active cancer and comorbidities, with additional risk observed in NHB patients and those living in zip codes with median household income &lt;$30\u2009000.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1388","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T10:22:56Z","timestamp":1621506176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rapid real\u2010world data analysis of patients with cancer, with and without <scp>COVID<\/scp>\u201019, across distinct health systems"],"prefix":"10.1002","volume":"4","author":[{"given":"Clara","family":"Hwang","sequence":"first","affiliation":[{"name":"Henry Ford Cancer Institute Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika A.","family":"Izano","sequence":"additional","affiliation":[{"name":"Syapse  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Aurora Cancer Care Advocate Aurora Health  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirish M.","family":"Gadgeel","sequence":"additional","affiliation":[{"name":"Henry Ford Cancer Institute Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Weese","sequence":"additional","affiliation":[{"name":"Aurora Cancer Care Advocate Aurora Health  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Henry Ford Cancer Institute Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Schrag","sequence":"additional","affiliation":[{"name":"Syapse  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahder","family":"Teka","sequence":"additional","affiliation":[{"name":"Syapse  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetal","family":"Walters","sequence":"additional","affiliation":[{"name":"Syapse  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-2889","authenticated-orcid":false,"given":"Frank M.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Syapse  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Syapse  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna R.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Oncology Center of Excellence United States Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"Kluetz","sequence":"additional","affiliation":[{"name":"Oncology Center of Excellence United States Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Oncology Center of Excellence United States Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Syapse  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Johns Hopkins University & Medicine.COVID\u201019 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University.2020;https:\/\/coronavirus.jhu.edu\/map.html. 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